Megaintestine in claudin-15-deficient mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 134; no. 2; p. 523
• Main Authors: Tamura, Atsushi, Kitano, Yuka, Hata, Masaki, Katsuno, Tatsuya, Moriwaki, Kazumasa, Sasaki, Hiroyuki, Hayashi, Hisayoshi, Suzuki, Yuichi, Noda, Tetsuo, Furuse, Mikio, Tsukita, Shoichiro, Tsukita, Sachiko
• Format: Journal Article
• Language: English
• Published: United States 01.02.2008
• Subjects: Animals; Cell Proliferation; Claudins; Epithelium - metabolism; Epithelium - pathology; Epithelium - ultrastructure; Gene Deletion; Intestinal Diseases - genetics; Intestine, Small - growth & development; Intestine, Small - metabolism; Intestine, Small - pathology; Intestine, Small - ultrastructure; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Phenotype; Tight Junctions - metabolism; Tight Junctions - pathology; Tight Junctions - ultrastructure

Claudins, the major components of tight junction (TJ) strands, which form paracellular barriers, consist of 24 family members, the combination of which determines the properties of TJ-based paracellular barriers. Here, we generated claudin-15-deficient (Cldn15(-/-)) mice to examine the ubiquitously...