Severe oral mucositis relating to pain and worse oral condition among patients with solid tumors undergoing treatment with FOLFIRI and 5-FU: a retrospective study
BACKGROUNDThere is a need for studies that correlate the severity of oral mucositis (OM) with chemotherapy protocols, transient myelosuppression and oral health. OBJECTIVETo analyze the severity of OM among individuals with solid tumors during hospitalization and its correlation with the type of che...
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| Published in | São Paulo medical journal Vol. 140; no. 4; pp. 588 - 594 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Portuguese |
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Associação Paulista de Medicina - APM
01.08.2022
Associação Paulista de Medicina |
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| Abstract | BACKGROUNDThere is a need for studies that correlate the severity of oral mucositis (OM) with chemotherapy protocols, transient myelosuppression and oral health. OBJECTIVETo analyze the severity of OM among individuals with solid tumors during hospitalization and its correlation with the type of chemotherapy, myelosuppression and oral health condition. DESIGN AND SETTINGRetrospective study at a public hospital in Bauru, state of São Paulo, Brazil, that is a regional referral center. METHODSIndividuals diagnosed with solid malignant tumors who received chemotherapy during hospitalization for completion of the antineoplastic treatment cycle or who presented complications resulting from this were assessed. RESULTSTwenty-eight individuals (24.3%) manifested some degree of OM. The most prevalent degrees of OM according to the World Health Organization (WHO) and modified WHO classification were grades 2 (11.3%) and 5 (4.3%), respectively. It was observed that the higher the OM-WHO (P < 0.001; r = 0.306) and modified OM-WHO (P < 0.001; r = 0.295) classifications were, the greater the oral pain reported by the individuals was. Presence of mucositis in the upper lip and buccal mucosa contributed to increased severity of OM and worsening of swallowing during hospitalization. Thus, severe OM was associated with use of the FOLFIRI protocol (folinic acid, fluorouracil and irinotecan). CONCLUSIONIndividuals with tumors who presented severe OM had greater severity of oral pain and worse oral health. Use of the FOLFIRI protocol was associated with higher prevalence of severe OM, while use of 5-fluorouracil (5-FU) was correlated with worse oral condition. |
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| AbstractList | ABSTRACT BACKGROUND: There is a need for studies that correlate the severity of oral mucositis (OM) with chemotherapy protocols, transient myelosuppression and oral health. OBJECTIVE: To analyze the severity of OM among individuals with solid tumors during hospitalization and its correlation with the type of chemotherapy, myelosuppression and oral health condition. DESIGN AND SETTING: Retrospective study at a public hospital in Bauru, state of São Paulo, Brazil, that is a regional referral center. METHODS: Individuals diagnosed with solid malignant tumors who received chemotherapy during hospitalization for completion of the antineoplastic treatment cycle or who presented complications resulting from this were assessed. RESULTS: Twenty-eight individuals (24.3%) manifested some degree of OM. The most prevalent degrees of OM according to the World Health Organization (WHO) and modified WHO classification were grades 2 (11.3%) and 5 (4.3%), respectively. It was observed that the higher the OM-WHO (P < 0.001; r = 0.306) and modified OM-WHO (P < 0.001; r = 0.295) classifications were, the greater the oral pain reported by the individuals was. Presence of mucositis in the upper lip and buccal mucosa contributed to increased severity of OM and worsening of swallowing during hospitalization. Thus, severe OM was associated with use of the FOLFIRI protocol (folinic acid, fluorouracil and irinotecan). CONCLUSION: Individuals with tumors who presented severe OM had greater severity of oral pain and worse oral health. Use of the FOLFIRI protocol was associated with higher prevalence of severe OM, while use of 5-fluorouracil (5-FU) was correlated with worse oral condition. BACKGROUNDThere is a need for studies that correlate the severity of oral mucositis (OM) with chemotherapy protocols, transient myelosuppression and oral health. OBJECTIVETo analyze the severity of OM among individuals with solid tumors during hospitalization and its correlation with the type of chemotherapy, myelosuppression and oral health condition. DESIGN AND SETTINGRetrospective study at a public hospital in Bauru, state of São Paulo, Brazil, that is a regional referral center. METHODSIndividuals diagnosed with solid malignant tumors who received chemotherapy during hospitalization for completion of the antineoplastic treatment cycle or who presented complications resulting from this were assessed. RESULTSTwenty-eight individuals (24.3%) manifested some degree of OM. The most prevalent degrees of OM according to the World Health Organization (WHO) and modified WHO classification were grades 2 (11.3%) and 5 (4.3%), respectively. It was observed that the higher the OM-WHO (P < 0.001; r = 0.306) and modified OM-WHO (P < 0.001; r = 0.295) classifications were, the greater the oral pain reported by the individuals was. Presence of mucositis in the upper lip and buccal mucosa contributed to increased severity of OM and worsening of swallowing during hospitalization. Thus, severe OM was associated with use of the FOLFIRI protocol (folinic acid, fluorouracil and irinotecan). CONCLUSIONIndividuals with tumors who presented severe OM had greater severity of oral pain and worse oral health. Use of the FOLFIRI protocol was associated with higher prevalence of severe OM, while use of 5-fluorouracil (5-FU) was correlated with worse oral condition. |
| Author | Almeida, Laura Costa de Maciel, Aloizio Premoli Manzano, Brena Rodrigues Orcina, Bernardo da Fonseca Santos, Dayanne dos Santos, Paulo Sérgio da Silva |
| AuthorAffiliation | Universidade de São Paulo |
| AuthorAffiliation_xml | – name: Universidade de São Paulo |
| Author_xml | – sequence: 1 givenname: Laura Costa de orcidid: 0000-0002-8403-5141 surname: Almeida fullname: Almeida, Laura Costa de organization: , Brazil – sequence: 2 givenname: Bernardo da Fonseca orcidid: 0000-0003-3367-483X surname: Orcina fullname: Orcina, Bernardo da Fonseca organization: Universidade de Sao Paulo, Brazil – sequence: 3 givenname: Aloizio Premoli orcidid: 0000-0002-7062-0630 surname: Maciel fullname: Maciel, Aloizio Premoli organization: Universidade de Sao Paulo, Brazil – sequence: 4 givenname: Dayanne dos orcidid: 0000-0002-1899-3499 surname: Santos fullname: Santos, Dayanne dos organization: Universidade de Sao Paulo, Brazil – sequence: 5 givenname: Brena Rodrigues orcidid: 0000-0003-0412-2243 surname: Manzano fullname: Manzano, Brena Rodrigues organization: Universidade de Sao Paulo, Brazil – sequence: 6 givenname: Paulo Sérgio da Silva orcidid: 0000-0002-0674-3759 surname: Santos fullname: Santos, Paulo Sérgio da Silva organization: Universidade de Sao Paulo, Brazil |
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| Cites_doi | 10.1590/s1679-45082018rw4007 10.1002/cncr.20162 10.1016/j.ijrobp.2007.01.053 10.1159/000499720 10.1007/s005200050004 10.1016/S1368-8375(98)00068-2 10.3390/ijerph17072464 10.1016/S1368-8375(02)00033-7 10.5005/jp-journals-10005-1428 10.1136/emj.18.3.205 10.1016/j.cden.2013.12.005 10.4103/0019-509X.75836 10.1016/j.iccn.2013.04.001 10.1111/j.1399-0012.2010.01283.x 10.3390/ijerph17041235 10.6061/clinics/2013(06)11 10.1007/s00520-011-1314-6 10.1097/CCO.0000000000000180 10.1007/s00520-011-1126-8 10.1093/jncimonographs/lgz016 10.1002/cncr.11671 10.1067/moe.2002.126018 10.1097/MPH.0000000000000970 |
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| Keywords | Oral medicine Stomatitis Chemotherapy Stomatology Oral mucositis Drug therapy Pathology, oral Dental service, hospital Oral health |
| Language | English Portuguese |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Laura Costa de Almeida: methodology, project administration, writing-original draft and writing-review and editing; Bernardo da Fonseca Orcina: methodology, project administration, supervision, writing-original draft and writing-review and editing; Aloizio Premoli Maciel: methodology, project administration, supervision, writing-original draft and writing-review and editing; Dayanne dos Santos: visualization, writing-original draft and writing-review and editing; Brena Rodrigues Manzano: methodology, project administration, supervision, writing-original draft and writing review and editing; and Paulo Sérgio da Silva Santos: methodology, project administration, supervision, writing-original draft and writing-review and editing. All authors reviewed and approved the final version for publication Authors’ contributions Conflict: None |
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Oster, G; Ford, CM; Lu, J; Sonis, S – volume: 25 start-page: 325 issue: 2 year: 2011 end-page: 328 article-title: Impact of oral care prior to HSCT on the severity and clinical outcomes of oral mucositis publication-title: Clin Transplant contributor: fullname: Santos, PS; Coracin, FL; Barros, JC – year: 1979 publication-title: WHO handbook for reporting results of cancer treatment – volume: 20 start-page: 395 issue: 2 year: 2012 end-page: 403 article-title: Association of oral mucositis with quality of life and symptom clusters in patients with solid tumors receiving chemotherapy publication-title: Support Care Cancer contributor: fullname: Kim, JW; Cha, Y; Kim, SJ – volume: 17 start-page: 2464 issue: 7 year: 2020 end-page: 2464 article-title: Oncological-therapy related oral mucositis as an interdisciplinary problem – literature review publication-title: Int J Environ Res Public Health contributor: fullname: Kusial, A; Jereczek-Fossa, BA; Cichońska, D; Alterio, D – volume: 7 start-page: 337 issue: 40 year: 2003 end-page: 340 article-title: Oral complications of antineoplastic chemotherapy publication-title: JBC J Bras Clin Odontol Integr contributor: fullname: Alves, FA; Coracin, FL; Gasparetto, PF; Correa, MEP – volume: 68 start-page: 792 issue: 6 year: 2013 end-page: 796 article-title: Oral health as a predictive factor for oral mucositis publication-title: Clinics (Sao Paulo) contributor: fullname: Coracin, FL; Santos, PS; Gallottini, MH – volume: 2019 issue: 53 year: 2019 article-title: Salivary Gland Hypofunction and Xerostomia in Head and Neck Radiation Patients publication-title: J Natl Cancer Inst Monogr contributor: fullname: Jensen, SB; Vissink, A; Limesand, KH; Reyland, ME – volume: 20 start-page: 2053 issue: 9 year: 2012 end-page: 2059 article-title: Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas publication-title: Support Care Cancer contributor: fullname: Nishimura, N; Nakano, K; Ueda, K – volume: 42 start-page: 342 issue: 6 year: 2019 end-page: 349 article-title: Physical and Psychological Impairments Associated with Mucositis after Oral Cancer Treatment and Their Impact on Quality of Life publication-title: Oncol Res Treat contributor: fullname: Jehn, P; Stier, R; Tavassol, F – volume: 18 start-page: 205 issue: 3 year: 2001 end-page: 207 article-title: The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain publication-title: Emerg Med J contributor: fullname: Kelly, AM – volume: 94 start-page: 39 issue: 1 year: 2002 end-page: 44 article-title: The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: a review of the literature publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod contributor: fullname: Epstein, JB; Tsang, AH; Warkentin, D; Ship, JA – volume: 8 start-page: 366 issue: 5 year: 2000 end-page: 371 article-title: Oral mucositis in patients treated with chemotherapy for solid tumors: a retrospective analysis of 150 cases publication-title: Support Care Cancer contributor: fullname: Raber-Durlacher, JE; Weijl, NI; Abu Saris, M – volume: 68 start-page: 1110 issue: 4 year: 2007 end-page: 1120 article-title: Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies publication-title: Int J Radiat Oncol Biol Phys (New York) contributor: fullname: Elting, LS; Cooksley, CD; Chambers, MS; Garden, AS – volume: 10 start-page: 166 issue: 2 year: 2017 end-page: 171 article-title: Prevalence of Oral Complications occurring in a Population of Pediatric Cancer Patients receiving Chemotherapy publication-title: Int J Clin Pediatr Dent contributor: fullname: Gandhi, K; Datta, G; Ahuja, S; Saxena, T; G Datta, A – volume: 39 start-page: 91 issue: 2 year: 2003 end-page: 100 article-title: Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions publication-title: Oral Oncol contributor: fullname: Barasch, A; Peterson, DE – volume: 27 start-page: 159 issue: 3 year: 2015 end-page: 164 article-title: Mucositis: pathobiology and management publication-title: Curr Opin Oncol (Philadelphia) contributor: fullname: Villa, A; Sonis, ST – volume: 100 start-page: 1995 year: 2004 end-page: 2025 article-title: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients publication-title: Cancer contributor: fullname: Sonis, ST; 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| SubjectTerms | Chemotherapy Dental service, hospital Drug therapy MEDICINE, GENERAL & INTERNAL Oral health Oral medicine Oral mucositis Original Pathology, oral Stomatitis Stomatology |
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| Title | Severe oral mucositis relating to pain and worse oral condition among patients with solid tumors undergoing treatment with FOLFIRI and 5-FU: a retrospective study |
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