The interaction and binding of flavonoids to human serum albumin modify its conformation, stability and resistance against aggregation and oxidative injuries - Barreca, Davide; Laganà, Giuseppina; Toscano, Giovanni; Calandra, Pietro; Kiselev, Mikhail A.; Lombardo, Domenico; Bellocco, Ersilia (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Binding Sites; electrophoresis; Flavonoid; flavonoids; Flavonoids - metabolism; Fluorescence; Fourier transform infrared spectroscopy; FTIR; glucose; Human serum albumin; Humans; hydrogen bonding; hydrophobicity; ligands; medicinal properties; Microscopy, Fluorescence; Models, Molecular; molecular models; oxidation; Oxidative Stress; Oxidative stresses and protein fibrillation; Phloretin - chemistry; Protein Aggregates; Protein Binding; Protein Conformation; protein degradation; protein structure; Proteolysis; Serum Albumin - chemistry; Serum Albumin - metabolism; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamic and kinetic variations; Thermodynamics; Fluorescence; Human serum albumin; Thermodynamic and kinetic variations; Flavonoid; FTIR; Oxidative stresses and protein fibrillation