Polysaccharide-protein complex from coelomic fluid of Dendrobaena veneta earthworm exerts a multi-pathway antiplatelet effect without coagulopathy and cytotoxicity

• Published in: Biomedicine & pharmacotherapy Vol. 151; p. 113205
• Main Authors: Poniedziałek, Barbara, Rosińska, Joanna, Rzymski, Piotr, Fiołka, Marta
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.07.2022
• Subjects: Adenosine Diphosphate; Animals; Aspirin - pharmacology; Blood Platelets; Cardiovascular disease; Human platelet; Humans; Natural antiplatelet agents; Oligochaeta; Platelet Aggregation; Platelet Aggregation Inhibitors - pharmacology; Polysaccharides - pharmacology; Thrombosis; Cardiovascular disease; Thrombosis; Natural antiplatelet agents; Human platelet

There is a pressing need to identify novel antiplatelet agents, an alternative to acetylsalicylic acid and thienopyridines, to broaden the prevention of cardiovascular events, the leading cause of global morbidity and mortality. Invertebrate coelomocytes structurally and functionally resemble the th...