Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1009 - 1023
• Main Authors: Strzelecka-Kiliszek, Agnieszka, Mebarek, Saida, Roszkowska, Monika, Buchet, René, Magne, David, Pikula, Slawomir
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: adhesion; Animals; apoptosis; Bone cells; bone formation; bone resorption; Calcification, Physiologic - physiology; cartilage; Cell Differentiation - physiology; chondrocytes; Differentiation; extracellular matrix; guanosinetriphosphatase; Humans; hypertrophy; metals; Mineralization; Monomeric GTP-Binding Proteins - metabolism; osteoarthritis; osteoblasts; Osteoblasts - metabolism; osteoclasts; phosphotransferases (kinases); rho GTP-Binding Proteins - metabolism; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - metabolism; ROCK; Signal transduction; stem cells; Vesicles; RANKL; PS; ROCK; ALP; MLC; PTH; NPP1; AnxA; OPN; PHD; TNAP; PI3-K; Signal transduction; Vesicles; PLA, PLC, PLD; RBD; Mineralization; Pi; SM; AGC; CHOL; BSP; MLCK; BMP; DMPK; CysD; PPi; MVs; MAPK; ECM; MMP; MARCKS; LIMK; HA; Bone cells; OCN; LPA; Differentiation; ANK

Members of Rho-associated coiled-coil kinases (ROCKs) are effectors of Rho family of small GTPases. ROCKs have multiple functions that include regulation of cellular contraction and polarity, adhesion, motility, proliferation, apoptosis, differentiation, maturation and remodeling of the extracellula...