Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)–Infected Individuals Without HTLV-1–Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study

• Published in: Clinical infectious diseases Vol. 61; no. 1; pp. 49 - 56
• Main Authors: Tanajura, Davi, Castro, Néviton, Oliveira, Paulo, Neto, Abraão, Muniz, André, Carvalho, Natália B., Orge, Glória, Santos, Silvane, Glesby, Marshall J., Carvalho, Edgar M.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2015
• Series: Editor's choice
• Subjects: Adult; Aged; and Commentaries; ARTICLES AND COMMENTARIES; Clinical outcomes; Female; HTLV-I Infections - complications; Human T-lymphotropic virus 1; Humans; Incidence; Infectious diseases; Longitudinal Studies; Male; Middle Aged; Nervous System Diseases - epidemiology; Nervous System Diseases - pathology; Neurology; Risk Factors; HAM/TSP; cohort; HTLV-1; neurologic manifestations; incidence

Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is the agent of HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP), observed in up to 5% of infected individuals. Despite low prevalence, many HTLV-1–infected patients who do not fulfill criteria for HAM/TSP present with ne...