The mechanism of RNA oxidation involved in the development of heart failure

• Published in: Free Radical Research Vol. 53; no. 8; pp. 910 - 921
• Main Authors: Liu, Tong, Cai, Jian-Ping, Zhang, Li-Qun, Sun, Ning, Cui, Ju, Wang, Hua, Yang, Jie-Fu
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.08.2019; Informa UK Limited
• Subjects: 8-Hydroxy-2'-Deoxyguanosine - analysis; 8-Hydroxyguanosine; Animals; Chromatography, Liquid; Dahl salt-sensitive rat; Gene Expression Regulation; Guanosine - analogs & derivatives; Guanosine - analysis; heart failure; Heart Failure - genetics; Heart Failure - metabolism; Humans; Male; MAP Kinase Signaling System; Myocardium - metabolism; Oxidation-Reduction; Pyrophosphatases - genetics; Pyrophosphatases - metabolism; Rats; RNA - chemistry; RNA - metabolism; RNA oxidation; Tandem Mass Spectrometry; heart failure; Dahl salt-sensitive rat; 8-Hydroxyguanosine; RNA oxidation

Heart failure (HF) has become a global public health problem due to its unclear pathogenesis. Our previous studies have found that RNA oxidation is associated with the occurrence and development of a variety of chronic diseases in the elderly, but whether RNA oxidation is related to the pathogenesis...