Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity

• Published in: Biochimica et biophysica acta Vol. 1840; no. 3; pp. 1152 - 1162
• Main Authors: Kodama, Azusa, Watanabe, Hiroshi, Tanaka, Ryota, Kondo, Masumi, Chuang, Victor Tuan Giam, Wu, Qiong, Endo, Masayuki, Ishima, Yu, Fukagawa, Masafumi, Otagiri, Masaki, Maruyama, Toru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2014
• Subjects: acetylcysteine; Acute kidney injury; albumins; animal models; Animals; anti-inflammatory activity; anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents - toxicity; Antioxidants - pharmacology; Apoptosis - drug effects; beta-N-acetylhexosaminidase; blood circulation; blood serum; cisplatin; Cisplatin - toxicity; Cisplatin nephrotoxicity; creatinine; fluorescein; Fusion protein; glutathione; Humans; Inflammation; interleukin-1beta; interleukin-6; intravenous injection; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; kidney diseases; kidneys; Male; Mice; Mice, Inbred ICR; nephrotoxicity; Oxidative stress; Pichia; reactive oxygen species; Reactive Oxygen Species - metabolism; renoprotective effect; Serum Albumin - metabolism; Serum Albumin - pharmacology; Thioredoxin; Thioredoxins - metabolism; Thioredoxins - pharmacology; tumor necrosis factor-alpha; urea nitrogen; Oxidative stress; Inflammation; Thioredoxin; Fusion protein; Acute kidney injury; Cisplatin nephrotoxicity

A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, has a short retention time in the blood. A long acting form of Trx, human serum albumin-Trx (HSA-Trx), was produ...