Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity - Kodama, Azusa; Watanabe, Hiroshi; Tanaka, Ryota; Kondo, Masumi; Chuang, Victor Tuan Giam; Wu, Qiong; Endo, Masayuki; Ishima, Yu; Fukagawa, Masafumi; Otagiri, Masaki; Maruyama, Toru (Biochimica et biophysica acta, 2014)
Keywords: acetylcysteine; Acute kidney injury; albumins; animal models; Animals; anti-inflammatory activity; anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Antineoplastic Agents - toxicity; Antioxidants - pharmacology; Apoptosis - drug effects; beta-N-acetylhexosaminidase; blood circulation; blood serum; cisplatin; Cisplatin - toxicity; Cisplatin nephrotoxicity; creatinine; fluorescein; Fusion protein; glutathione; Humans; Inflammation; interleukin-1beta; interleukin-6; intravenous injection; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; kidney diseases; kidneys; Male; Mice; Mice, Inbred ICR; nephrotoxicity; Oxidative stress; Pichia; reactive oxygen species; Reactive Oxygen Species - metabolism; renoprotective effect; Serum Albumin - metabolism; Serum Albumin - pharmacology; Thioredoxin; Thioredoxins - metabolism; Thioredoxins - pharmacology; tumor necrosis factor-alpha; urea nitrogen; Oxidative stress; Inflammation; Thioredoxin; Fusion protein; Acute kidney injury; Cisplatin nephrotoxicity