Nonmetric Multidimensional Scaling Corrects for Population Structure in Association Mapping With Different Sample Types

• Published in: Genetics (Austin) Vol. 182; no. 3; pp. 875 - 888
• Main Authors: Zhu, Chengsong, Yu, Jianming
• Format: Journal Article
• Language: English
• Published: United States Genetics Soc America 01.07.2009; Genetics Society of America
• Subjects: Algorithms; Arabidopsis - genetics; Chromosome Mapping - methods; Crosses, Genetic; Frequency distribution; Genetics; Genetics, Population; Genome, Plant - genetics; Genome-Wide Association Study - methods; Genotype; Investigations; Methods; Models, Genetic; Multivariate analysis; Phenotype; Plants - genetics; Pollination - genetics; Polymorphism, Single Nucleotide; Population; Population structure; Principal components analysis; Quantitative Trait, Heritable; Research methodology; Simulation; Statistical methods; Studies; Zea mays - genetics

Recent research has developed various promising methods to control for population structure in genomewide association mapping of complex traits, but systematic examination of how well these methods perform under different genetic scenarios is still lacking. Appropriate methods for controlling geneti...