Social isolation from early life induces anxiety-like behaviors in adult rats: Relation to neuroendocrine and neurochemical dysfunctions

• Published in: Biomedicine & pharmacotherapy Vol. 158; p. 114181
• Main Authors: Dimonte, Stefania, Sikora, Vladyslav, Bove, Maria, Morgese, Maria Grazia, Tucci, Paolo, Schiavone, Stefania, Trabace, Luigia
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.02.2023
• Subjects: Animals; Anxiety; Anxiety - metabolism; Behavior, Animal; gamma-Aminobutyric Acid - metabolism; Male; Neurochemistry; Neuroendocrine modulators; Norepinephrine - metabolism; Psychosis; Rats; Serotonin - metabolism; Social Isolation; Psychosis; Neurochemistry; Neuroendocrine modulators; Anxiety; Social isolation

Subjects suffering from psychosis frequently experience anxiety. However, mechanisms underlying this comorbidity remain still unclear. We investigated whether neurochemical and neuroendocrine dysfunctions were involved in the development of anxiety-like behavior in a rodent model of psychotic-like s...