Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 1; p. 129776
• Main Authors: Hashimoto, Misuzu, Fukamizu, Akiyoshi, Nakagawa, Tsutomu, Kizuka, Yasuhiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: amyotrophic lateral sclerosis; Animals; arginine; Arginine - analogs & derivatives; Arginine - genetics; Arginine - metabolism; Arginine methylation; astrocytes; brain; Brain - growth & development; Brain - metabolism; Brain - pathology; Central nervous system (CNS); dementia; DNA damage; Gene Expression Regulation, Developmental; histones; Humans; Methylation; Neural Stem Cells - metabolism; Neural Stem Cells - pathology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; neurodevelopment; oligodendroglia; Protein arginine methyltransferase 1 (PRMT1); Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; type I protein arginine methyltransferase; CNS; Protein arginine methyltransferase 1 (PRMT1); PRMT1; Central nervous system (CNS); Arginine methylation; NSC

Protein arginine methyltransferase 1 (PRMT1), a major type I arginine methyltransferase in mammals, methylates histone and non-histone proteins to regulate various cellular functions such as transcription, DNA damage response, and signal transduction. This review summarizes previous and recent studi...