Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

• Published in: Biochimica et biophysica acta Vol. 1860; no. 4; pp. 727 - 745
• Main Authors: de Oliveira, Marcos Roberto, Nabavi, Seyed Fazel, Manayi, Azadeh, Daglia, Maria, Hajheydari, Zohreh, Nabavi, Seyed Mohammad
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2016
• Subjects: Animals; apoptosis; Apoptosis - drug effects; bioavailability; biogenesis; calcium; energy metabolism; Humans; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Natural products; neoplasms; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; neurodegenerative diseases; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Oxidative stress; Polyphenols; power plants; red wines; Resveratrol; signal transduction; Stilbenes - therapeutic use; therapeutics; ultrastructure; Polyphenols; Oxidative stress; Mitochondria; Natural products; Resveratrol

Mitochondria, the power plants of the cell, are known as a cross-road of different cellular signaling pathways. These cytoplasmic double-membraned organelles play a pivotal role in energy metabolism and regulate calcium flux in the cells. It is well known that mitochondrial dysfunction is associated...