Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis With Vasopressor-Dependent Shock: A Propensity Score–Matched Analysis From 130 US Hospitals

• Published in: Clinical infectious diseases Vol. 64; no. 7; pp. 877 - 885
• Main Authors: Kadri, Sameer S., Swihart, Bruce J., Bonne, Stephanie L., Hohmann, Samuel F., Hennessy, Laura V., Louras, Peter, Evans, Heather L., Rhee, Chanu, Suffredini, Anthony F., Hooper, David C., Follmann, Dean A., Bulger, Eileen M., Danner, Robert L.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics; ARTICLES AND COMMENTARIES; Comorbidity; Editor's Choice; Fasciitis, Necrotizing - complications; Fasciitis, Necrotizing - diagnosis; Fasciitis, Necrotizing - drug therapy; Fasciitis, Necrotizing - mortality; Female; Hospital Mortality; Hospitals; Humans; Immunoglobulins; Immunoglobulins, Intravenous - therapeutic use; Major; Male; Middle Aged; Mortality; Odds Ratio; Propensity Score; Retrospective Studies; Severity of Illness Index; Shock - complications; Shock - diagnosis; Shock - drug therapy; Shock - mortality; Shock, Septic - complications; Shock, Septic - drug therapy; Shock, Septic - mortality; Staphylococcus aureus; Staphylococcus infections; Streptococcus; Streptococcus pyogenes; Treatment Outcome; United States; Young Adult; United States > US; toxic shock; intravenous immunoglobulin; necrotizing fasciitis

Background. Shock frequently complicates necrotizing fasciitis (NF) caused by group A Streptococcus (GAS) or Staphylococcus aureus. Intravenous immunoglobulin (IVIG) is sometimes administered for presumptive toxic shock syndrome (TSS), but its frequency of use and efficacy are unclear. Methods. Adul...