Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial

• Published in: British journal of nutrition Vol. 114; no. 10; pp. 1638 - 1646
• Main Authors: Eskesen, Dorte, Jespersen, Lillian, Michelsen, Birgit, Whorwell, Peter J., Müller-Lissner, Stefan, Morberg, Cathrine M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.11.2015
• Subjects: Abdominal Pain - therapy; Adult; adults; Bifidobacterium; Bifidobacterium animalis subsp. lactis; Defecation; Diet; Double-Blind Method; Excretory system; Female; France; gastrointestinal system; Germany; Human and Clinical Nutrition; Humans; Male; Middle Aged; Nutrition; Odds Ratio; Patient Compliance; Placebos; Probiotics; Probiotics - administration & dosage; Probiotics - adverse effects; Surveys and Questionnaires; Time Factors; United Kingdom; Probiotics; Gastrointestinal well-being; Bowel habits; Bifidobacterium animalis subsp. lactis; Defecation frequency; IBS irritable bowel syndrome; PP per-protocol; GI gastrointestinal; ITT intention-to-treat; AE adverse events

The aim of the present study was to investigate the effect of Bifidobacterium animalis subsp. lactis, BB-12®, on two primary end points – defecation frequency and gastrointestinal (GI) well-being – in healthy adults with low defecation frequency and abdominal discomfort. A total of 1248 subjects wer...