Immunomodulatory Effects of Macrolide Antibiotics – Part 2: Advantages and Disadvantages of Long-Term, Low-Dose Macrolide Therapy

• Published in: Respiration Vol. 81; no. 1; pp. 75 - 87
• Main Authors: Altenburg, J., de Graaff, C.S., van der Werf, T.S., Boersma, W.G.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2011; S. Karger AG
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobial agents; Arrhythmia; Arrhythmias, Cardiac - chemically induced; Asthma; Bacterial Infections; Biological and medical sciences; Bronchiectasis; Chronic Disease; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; Clinical outcomes; Clinical trials; Cystic fibrosis; Data processing; Drug Administration Schedule; Drug Dosage Calculations; Drug Resistance, Bacterial; Drug therapy; Errors of metabolism; Fibrosis; Gastrointestinal Diseases - chemically induced; Heart; Humans; Immune system; Immunomodulation; Inflammation; Inflammatory diseases; Long-Term Care; Lung diseases; Macrolide antibiotics; Macrolides - administration & dosage; Macrolides - adverse effects; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Pathogens; Patient Selection; Pharmacology. Drug treatments; Pneumology; Randomized Controlled Trials as Topic; Respiration; Respiratory Tract Diseases - drug therapy; Respiratory Tract Diseases - microbiology; Respiratory Tract Diseases - physiopathology; Review; Side effects; Sinusitis; Time; Diffuse panbronchiolitis; Macrolides; Cystic fibrosis; Diffuse; Respiratory disease; Low dose; Metabolic diseases; Long term; Macrolide; Genetic disease; Bronchiolitis; Antibiotic; Treatment; Advantage; Disadvantage; Diffuse pan bronchiolitis; Digestive diseases; Bronchus disease; Antibacterial agent; Pancreatic disease; Pneumology

The available evidence for long-term, low-dose treatment with 14- and 15-membered ring macrolides in non-cystic fibrosis (CF) bronchiectasis, COPD, chronic sinusitis, and asthma is reviewed with special attention to possible adverse effects and the emergence of resistance during long-term macrolide...