PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance

• Published in: Environmental Pollution Vol. 254; no. Pt A; p. 112937
• Main Authors: Wang, Yan, Tang, Meng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2019
• Subjects: Antigens, CD - biosynthesis; antioxidant activity; Apoferritins - biosynthesis; Apoptosis - drug effects; biomarkers; cell death; chelating agents; Cyclohexylamines - pharmacology; deferoxamine; Deferoxamine - pharmacology; endothelial cells; Endothelial Cells - metabolism; Ferritins - biosynthesis; Ferroptosis; Ferroptosis - physiology; Glutathione - metabolism; glutathione peroxidase; Humans; iron; Iron - toxicity; iron absorption; Iron overload; Iron Overload - pathology; Lipid peroxidation; Lipid Peroxidation - drug effects; microarray technology; NADP (coenzyme); Oxidation-Reduction - drug effects; Particulate Matter - toxicity; particulates; Phenylenediamines - pharmacology; PM2.5; public health; Reactive Oxygen Species - metabolism; Receptors, Transferrin - biosynthesis; Redox imbalance; ROS; signal transduction; Signal Transduction - drug effects; Iron overload; Lipid peroxidation; Ferroptosis; Redox imbalance; PM2.5; ROS

PM2.5 is becoming a worldwide environmental problem, which profoundly endangers public health, thus progressively capturing public attention this decade. As a fragile target of PM2.5, the underlying mechanisms of endothelial cell damage are still obscure. According to the previous microarray data an...