Bone turnover markers in sheep and goat: A review of the scientific literature

Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations r...

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Published inAnais da Academia Brasileira de Ciências Vol. 89; no. 1; pp. 231 - 245
Main Authors Camassa, José A, Diogo, Camila C, Sousa, Cristina P, Azevedo, Jorge T, Viegas, Carlos A, Reis, Rui L, Dourado, Nuno, Dias, Isabel R
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Academia Brasileira de Ciências 2017
Subjects
Animals
Biomarkers - blood
Biomarkers - urine
Bone formation markers
bone metabolism
Bone Remodeling - physiology
Bone Resorption - metabolism
Bone Resorption - physiopathology
bone resorption markers
Fracture Healing - physiology
Goats - physiology
Models, Animal
MULTIDISCIPLINARY SCIENCES
Sheep - physiology
small ruminants
small ruminants
bone metabolism
Bone formation markers
bone resorption markers
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Abstract Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.
AbstractList ABSTRACT Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.
Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.
Author Camassa, José A
Viegas, Carlos A
Dias, Isabel R
Dourado, Nuno
Sousa, Cristina P
Reis, Rui L
Diogo, Camila C
Azevedo, Jorge T
AuthorAffiliation Universidade de Trás-os-Montes e Alto Douro
Center Hospitalar of Porto
Universidade do Minho
AuthorAffiliation_xml – name: Universidade de Trás-os-Montes e Alto Douro
– name: Center Hospitalar of Porto
– name: Universidade do Minho
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  givenname: José A
  surname: Camassa
  fullname: Camassa, José A
  organization: 1Department of Veterinary Sciences, Agricultural and Veterinary Sciences School/ ECAV, University of Trás-os-Montes and Alto Douro/ UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
– sequence: 2
  givenname: Camila C
  surname: Diogo
  fullname: Diogo, Camila C
  organization: 1Department of Veterinary Sciences, Agricultural and Veterinary Sciences School/ ECAV, University of Trás-os-Montes and Alto Douro/ UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
– sequence: 3
  givenname: Cristina P
  surname: Sousa
  fullname: Sousa, Cristina P
  organization: Center Hospitalar of Porto, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal
– sequence: 4
  givenname: Jorge T
  surname: Azevedo
  fullname: Azevedo, Jorge T
  organization: Centre for Animal Sciences and Veterinary Studies/ CECAV, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
– sequence: 5
  givenname: Carlos A
  surname: Viegas
  fullname: Viegas, Carlos A
  organization: Centre for the Research and Technology of Agro-Environmental and Biological Sciences/ CITAB, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
– sequence: 6
  givenname: Rui L
  surname: Reis
  fullname: Reis, Rui L
  organization: Life and Health Sciences Research Institute/ ICVS, School of Health Sciences, University of Minho Campus de Gualtar 4710-057 Braga, Portugal
– sequence: 7
  givenname: Nuno
  surname: Dourado
  fullname: Dourado, Nuno
  organization: Department of Mechanical Engineering, University of Minho, Azurém Campus, 4804-533 Guimarães, Portugal
– sequence: 8
  givenname: Isabel R
  surname: Dias
  fullname: Dias, Isabel R
  organization: Centre for the Research and Technology of Agro-Environmental and Biological Sciences/ CITAB, UTAD, Quinta de Prados, 5000-801 Vila Real, Portugal
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Issue 1
Keywords small ruminants
bone metabolism
Bone formation markers
bone resorption markers
Language English
Portuguese
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Snippet Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this...
ABSTRACT Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of...
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StartPage 231
SubjectTerms Animals
Biomarkers - blood
Biomarkers - urine
Bone formation markers
bone metabolism
Bone Remodeling - physiology
Bone Resorption - metabolism
Bone Resorption - physiopathology
bone resorption markers
Fracture Healing - physiology
Goats - physiology
Models, Animal
MULTIDISCIPLINARY SCIENCES
Sheep - physiology
small ruminants
Title Bone turnover markers in sheep and goat: A review of the scientific literature
URI https://www.ncbi.nlm.nih.gov/pubmed/28273244
https://search.proquest.com/docview/1891086678
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100231&lng=en&tlng=en
https://doaj.org/article/32d5f9c492454cb1970254fcd8db18cb
Volume 89
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