Dentin Matrix Protein-1 Activates Dental Pulp Fibroblasts

• Published in: Journal of endodontics Vol. 38; no. 1; pp. 75 - 80
• Main Authors: Abd-Elmeguid, Ashraf, Yu, Donald C., Kline, Loren W., Moqbel, Redwan, Vliagoftis, Harissios
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2012
• Subjects: Calcinosis - pathology; Cell Culture Techniques; Dental Pulp - cytology; Dental Pulp - immunology; Dentistry; DMP-1; Endocrinology & Metabolism; Enzyme Inhibitors - pharmacology; Extracellular Matrix Proteins - antagonists & inhibitors; Extracellular Matrix Proteins - pharmacology; Fibroblasts - drug effects; Fibroblasts - immunology; Humans; Imidazoles - pharmacology; Inflammation Mediators - antagonists & inhibitors; Interleukin-6 - analysis; Interleukin-8 - drug effects; Lipopolysaccharides - pharmacology; MAP Kinase Signaling System - drug effects; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; Phosphoproteins - antagonists & inhibitors; Phosphoproteins - pharmacology; pro-inflammatory cytokine; pulp fibroblasts; pulp inflammation; pulp repair; Pulpitis - pathology; Pyridines - pharmacology; SIBLING; Tooth, Impacted - pathology; pulp repair; DMP-1; pulp inflammation; pro-inflammatory cytokine; pulp fibroblasts; SIBLING

Dentin matrix protein-1 (DMP-1) is involved in the mineralization of hard dental tissues. DMP-1 is localized in several soft tissues, but its role is unclear. Human inflamed dental pulps were collected from the endodontic clinic and human normal pulps from impacted teeth. Dental pulp cells from 8 su...