Pharmacogenetics-based therapeutic recommendations - ready for clinical practice?

• Published in: Nature reviews. Drug discovery Vol. 4; no. 8; pp. 639 - 647
• Main Authors: Kirchheiner, Julia, Fuhr, Uwe, Brockmöller, Jürgen
• Format: Journal Article Book Review
• Language: English
• Published: England Nature Publishing Group 01.08.2005
• Subjects: Clinical trials; Clinical Trials as Topic - classification; Clinical Trials as Topic - methods; Drug Industry - methods; Drug Industry - trends; Drug Therapy - methods; Drug Therapy - trends; Drugs; Genetic polymorphisms; Humans; Management; Pharmacogenetics; Pharmacogenetics - methods; Pharmacogenetics - trends; Physiological aspects; Practice Patterns, Physicians' - trends; Product development; Terminology as Topic; United States

Although considerable progress has been made in basic pharmacogenetic research, less has been demonstrated in the application of pharmacogenetics (PGx)-based diagnostics to drug development and in clinical practice. There are drugs that are currently used in the clinic for which individualized thera...