Antinociceptive effect of LMH-2, a new sigma-1 receptor antagonist analog of haloperidol, on the neuropathic pain of diabetic mice - Ventura-Martínez, Rosa; Ángeles-López, Guadalupe Esther; González-Ugalde, Diana; Domínguez-Páez, Tania; Navarrete-Vázquez, Gabriel; Jaimez, Ruth; Déciga-Campos, Myrna (Biomedicine & pharmacotherapy, 2024)
Keywords: Analgesics - pharmacology; Animals; antiallodynic effect; antihyperalgesic effect; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetic Neuropathies - drug therapy; Dose-Response Relationship, Drug; Gabapentin - pharmacology; Haloperidol - pharmacology; Hyperalgesia - drug therapy; LMH-2; Male; Mice; Molecular Docking Simulation; Neuralgia - drug therapy; neuropathic pain; Receptors, sigma - antagonists & inhibitors; Receptors, sigma - metabolism; Sigma-1 Receptor; Streptozocin; SS; NA+STZ; D2R; TCs; S.c; I.p; σ1R; sigma-1 receptor; PRAM; antiallodynic effect; S.E.M; AUC; antihyperalgesic effect; HAL; N.s; neuropathic pain; Au; GBP; ANOVA; VEH; Ki; LMH-2