Urinary metabolic signatures of human adiposity

• Published in: Science translational medicine Vol. 7; no. 285; p. 285ra62
• Main Authors: Elliott, Paul, Posma, Joram M, Chan, Queenie, Garcia-Perez, Isabel, Wijeyesekera, Anisha, Bictash, Magda, Ebbels, Timothy M D, Ueshima, Hirotsugu, Zhao, Liancheng, van Horn, Linda, Daviglus, Martha, Stamler, Jeremiah, Holmes, Elaine, Nicholson, Jeremy K
• Format: Journal Article
• Language: English
• Published: United States 29.04.2015
• Subjects: Adiposity; Amino Acids, Branched-Chain - metabolism; Body Mass Index; Energy Metabolism; Humans; Metabolomics; Muscle, Skeletal - metabolism; Obesity - urine; Proton Magnetic Resonance Spectroscopy

Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton ((1)H) nuclear magnetic resonance (NMR) spectroscopy and ion exchange chromatography to characterize the metabolic signatures of adiposity in the U.S. (n = 1880) and UK (n = 444) cohorts of the...