Hb Wayne, the frameshift variant with extended alpha chains observed in a Caucasian family from Alabama

• Published in: Hemoglobin Vol. 8; no. 1; p. 1
• Main Authors: Huisman, T H, Headlee, M G, Wilson, J B, Lam, H, Johnson, S E, Webber, B B
• Format: Journal Article
• Language: English
• Published: England 1984
• Subjects: Adult; Child, Preschool; DNA - genetics; DNA Restriction Enzymes; Female; Genes; Hemoglobins, Abnormal - analysis; Hemoglobins, Abnormal - genetics; Heterozygote; Humans; Infant, Newborn; Male; Middle Aged; Mutation; Oxyhemoglobins - metabolism; Pedigree; Peptides - analysis; Protein Conformation

The presence of the alpha-globin frameshift mutant, Hb Wayne, in three generations of a second family is described. The data include a hematological evaluation of the four heterozygotes, structural characterization of the variant, the use of HPLC for the separation of tryptic and chymotryptic peptid...