Development and Course of Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials

• Published in: Ophthalmology (Rochester, Minn.) Vol. 125; no. 7; pp. 1037 - 1046
• Main Authors: Daniel, Ebenezer, Pan, Wei, Ying, Gui-shuang, Kim, Benjamin J., Grunwald, Juan E., Ferris, Frederick L., Jaffe, Glenn J., Toth, Cynthia A., Martin, Daniel F., Fine, Stuart L., Maguire, Maureen G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2018
• Subjects: Aged; Aged, 80 and over; Angiogenesis Inhibitors - therapeutic use; Choroidal Neovascularization - diagnosis; Choroidal Neovascularization - drug therapy; Choroidal Neovascularization - physiopathology; Cicatrix - epidemiology; Cicatrix - physiopathology; Clinical Trials as Topic; Cohort Studies; Female; Fibrosis; Fluorescein Angiography; Follow-Up Studies; Geographic Atrophy - epidemiology; Geographic Atrophy - physiopathology; Humans; Incidence; Intravitreal Injections; Kaplan-Meier Estimate; Macular Degeneration - diagnosis; Macular Degeneration - drug therapy; Macular Degeneration - physiopathology; Male; Middle Aged; Photography - methods; Prospective Studies; Retina - pathology; Risk Factors; Subretinal Fluid; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual Acuity - physiology; CATT; SD; CI; RPE; VEGF; nAMD; aHR; CNV; FA; VA; CFP; DA

To describe risk factors for scar formation and changes to fibrotic scar through 5 years in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). Multicenter, prospective cohort study. A total of 1061 subjects in CATT. Color photographic and fluorescein angiographic images fro...