Plant Extracts Display Synergism with Different Classes of Antibiotics
One manner in which plant-derived compounds exert their antibiotic potential is the synergism, a positive interaction between two compounds. Studies indicate that the use of plant extracts combined with antimicrobials may promote a significant reduction of the minimum inhibitory concentrations of an...
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| Published in | Anais da Academia Brasileira de Ciências Vol. 91; no. 2; p. e20180117 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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01.01.2019
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| Abstract | One manner in which plant-derived compounds exert their antibiotic potential is the synergism, a positive interaction between two compounds. Studies indicate that the use of plant extracts combined with antimicrobials may promote a significant reduction of the minimum inhibitory concentrations of antibiotics for bacterial strains. This study aimed to evaluate the activity of plant extracts and antibiotics as well as their combination on Staphylococcus aureus. The activity of 15 plant extracts was evaluated using diffusion assay. The minimum inhibitory concentrations (MICs) and the interactions between the extracts and antibiotics as well as compound emodin were evaluated with the checkerboard method. The active extracts were a hexane extract of the leaves of Baccharis dracunculifolia and the ethanol extracts of the leaves of Plectranthus ornatus, Inga edulis, Salvia officinalis and Senna macranthera. The Plectranthus ornatus extract displayed synergism with ampicillin (a β-lactam), kanamycin and gentamicin (aminoglycosides), with 8-fold reductions in the MIC. The same reduction was observed for the extracts of Salvia officinalis and Senna macranthera, which displayed the lowest MIC. Using these combinations resulted in a reduction in the minimum dose required for effective antimicrobial effects, which is interesting because it may decrease both the risk of side effects and the costs of treatment. |
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| AbstractList | One manner in which plant-derived compounds exert their antibiotic potential is the synergism, a positive interaction between two compounds. Studies indicate that the use of plant extracts combined with antimicrobials may promote a significant reduction of the minimum inhibitory concentrations of antibiotics for bacterial strains. This study aimed to evaluate the activity of plant extracts and antibiotics as well as their combination on Staphylococcus aureus. The activity of 15 plant extracts was evaluated using diffusion assay. The minimum inhibitory concentrations (MICs) and the interactions between the extracts and antibiotics as well as compound emodin were evaluated with the checkerboard method. The active extracts were a hexane extract of the leaves of Baccharis dracunculifolia and the ethanol extracts of the leaves of Plectranthus ornatus, Inga edulis, Salvia officinalis and Senna macranthera. The Plectranthus ornatus extract displayed synergism with ampicillin (a β-lactam), kanamycin and gentamicin (aminoglycosides), with 8-fold reductions in the MIC. The same reduction was observed for the extracts of Salvia officinalis and Senna macranthera, which displayed the lowest MIC. Using these combinations resulted in a reduction in the minimum dose required for effective antimicrobial effects, which is interesting because it may decrease both the risk of side effects and the costs of treatment. |
| Author | Costa, Priscilla A DA Ribon, Andréa O B Diaz, Marisa A N Purgato, Gislaine A Silva, Danielle M Gaspar, Diaz-Muñoz |
| AuthorAffiliation | Universidade Federal de Viçosa Universidade Federal de Minas Gerais |
| AuthorAffiliation_xml | – sequence: 0 name: Universidade Federal de Viçosa – sequence: 0 name: Universidade Federal de Minas Gerais |
| Author_xml | – sequence: 1 givenname: Danielle M surname: Silva fullname: Silva, Danielle M organization: Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil – sequence: 2 givenname: Priscilla A DA surname: Costa fullname: Costa, Priscilla A DA organization: Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil – sequence: 3 givenname: Andréa O B surname: Ribon fullname: Ribon, Andréa O B organization: Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil – sequence: 4 givenname: Gislaine A surname: Purgato fullname: Purgato, Gislaine A organization: Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil – sequence: 5 givenname: Diaz-Muñoz surname: Gaspar fullname: Gaspar, Diaz-Muñoz organization: Departamento de Química, Instituto de Ciências Exatas/ICEX, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil – sequence: 6 givenname: Marisa A N orcidid: 0000-0002-3370-4149 surname: Diaz fullname: Diaz, Marisa A N organization: Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil |
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| Cites_doi | 10.1631/jzus.B0920072 10.1590/S1516-05722009000400005 10.1016/j.cvfa.2012.03.005 10.2298/JSC0301017V 10.1016/j.phymed.2008.06.008 10.1590/S0102-695X1998000100003 10.5897/AJB11.440 10.1590/S1517-83822000000400003 10.1590/S0074-02762006000400007 10.1590/S0102-695X2010005000013 10.1016/j.cbpa.2004.04.011 10.3390/ijms10083400 10.1021/jf001494m 10.3168/jds.2011-4938 10.1002/ffj.1730 10.3168/jds.2011-5065 10.1016/S0378-8741(01)00411-1 10.1016/j.ijfoodmicro.2010.04.001 10.1186/1751-0147-53-36 |
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| Keywords | plant extract antibiotics bovine mastitis Staphylococcus aureus |
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| Title | Plant Extracts Display Synergism with Different Classes of Antibiotics |
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