ABC transporters as cancer drivers: Potential functions in cancer development

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 1; pp. 52 - 60
• Main Authors: Domenichini, Alice, Adamska, Aleksandra, Falasca, Marco
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2019
• Subjects: ABC transporters; ATP-binding cassette (ABC) transporters; bioactive compounds; Cancer biology; carcinogenesis; Cell signalling; Chemoresistance; drugs; Lipid transport; multiple drug resistance; neoplasms; therapeutics; Cell signalling; Cancer biology; Lipid transport; ATP-binding cassette (ABC) transporters; Chemoresistance

ABC transporters have attracted considerable attention for their function as drug transporters in a broad range of tumours and are therefore considered as major players in cancer chemoresistance. However, less attention has been focused on their potential role as active players in cancer development...