Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway

• Published in: Biochimica et biophysica acta Vol. 1850; no. 9; pp. 1751 - 1761
• Main Authors: Wang, Peng, Peng, Xiao, Wei, Zuo-Fu, Wei, Fu-Yao, Wang, Wei, Ma, Wei-Dong, Yao, Li-Ping, Fu, Yu-Jie, Zu, Yuan-Gang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: active ingredients; Active Transport, Cell Nucleus; antioxidant activity; Antioxidant gene; Antioxidants - metabolism; apoptosis; Cell Proliferation - drug effects; Cytoprotection; Cytoprotection - drug effects; dose response; Extracellular Signal-Regulated MAP Kinases - physiology; Geraniin; Geranium; Glucosides - pharmacology; glutathione; heme oxygenase (biliverdin-producing); Hep G2 Cells; human cell lines; Human hepatocarcinoma cell line; Humans; hydrogen peroxide; Hydrolyzable Tannins - pharmacology; MAP Kinase Signaling System - drug effects; membrane potential; mitochondrial membrane; Mitochondrial Membranes - drug effects; NADP (coenzyme); NF-E2-Related Factor 2; Nrf2; Oxidative stress; Oxidative Stress - drug effects; Phosphatidylinositol 3-Kinases - physiology; protective effect; Proto-Oncogene Proteins c-akt - physiology; signal transduction; Up-Regulation; Human hepatocarcinoma cell line; Oxidative stress; Antioxidant gene; Nrf2; Geraniin; Cytoprotection

Geraniin, an active compound with remarkable antioxidant activity, was isolated from Geranium sibiricum. The present study aimed to investigate whether geraniin has the ability to activate Nrf2, induce antioxidant enzyme expression and protect cells from oxidative damage. The cells were pretreated w...