Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway - Wang, Peng; Peng, Xiao; Wei, Zuo-Fu; Wei, Fu-Yao; Wang, Wei; Ma, Wei-Dong; Yao, Li-Ping; Fu, Yu-Jie; Zu, Yuan-Gang (Biochimica et biophysica acta, 2015)
Keywords: active ingredients; Active Transport, Cell Nucleus; antioxidant activity; Antioxidant gene; Antioxidants - metabolism; apoptosis; Cell Proliferation - drug effects; Cytoprotection; Cytoprotection - drug effects; dose response; Extracellular Signal-Regulated MAP Kinases - physiology; Geraniin; Geranium; Glucosides - pharmacology; glutathione; heme oxygenase (biliverdin-producing); Hep G2 Cells; human cell lines; Human hepatocarcinoma cell line; Humans; hydrogen peroxide; Hydrolyzable Tannins - pharmacology; MAP Kinase Signaling System - drug effects; membrane potential; mitochondrial membrane; Mitochondrial Membranes - drug effects; NADP (coenzyme); NF-E2-Related Factor 2; Nrf2; Oxidative stress; Oxidative Stress - drug effects; Phosphatidylinositol 3-Kinases - physiology; protective effect; Proto-Oncogene Proteins c-akt - physiology; signal transduction; Up-Regulation; Human hepatocarcinoma cell line; Oxidative stress; Antioxidant gene; Nrf2; Geraniin; Cytoprotection