Loss of perivascular aquaporin‐4 in idiopathic normal pressure hydrocephalus

• Published in: Glia Vol. 67; no. 1; pp. 91 - 100
• Main Authors: Hasan‐Olive, Md Mahdi, Enger, Rune, Hansson, Hans‐Arne, Nagelhus, Erlend A., Eide, Per Kristian
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2019; Wiley Subscription Services, Inc
• Subjects: Amyloid; aqp4; Aquaporin 4; Aquaporins; association; astrocytes; Brain; Cerebrospinal fluid; Channels; Clinical Medicine; Contrast agents; Cortex (entorhinal); Cytochemistry; deletion; Dementia; Dementia disorders; Density; Drainage channels; Drainage control; Electron microscopy; Endothelial cells; glia; glymphatic; Hydrocephalus; idiopathic normal pressure; idiopathic normal pressure hydrocephalus; immunogold cytochemistry; immunogold electron microscopy; Klinisk medicin; localization; Magnetic resonance imaging; Membranes; Metabolites; Neurodegeneration; Neuroimaging; NMR; Nuclear magnetic resonance; Parenchyma; Patients; polarization; Pressure; retinal muller cells; shunt; Solutes; surgery; Water circulation; water transport; aquaporin-4; immunogold electron microscopy; cerebrospinal fluid; glymphatic; astrocytes; glia; idiopathic normal pressure hydrocephalus

Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of dementia that may be successfully treated with cerebrospinal fluid (CSF) diversion. Recently, magnetic resonance imaging (MRI) using a MRI contrast agent as a CSF tracer revealed impaired clearance of the CSF tracer from various brain r...