Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration

• Published in: Birth defects research. Part C. Embryo today Vol. 99; no. 3; pp. 170 - 191
• Main Authors: Dirckx, Naomi, Van Hul, Matthias, Maes, Christa
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2013; Wiley Subscription Services, Inc
• Subjects: angiogenesis; Animals; Bone and Bones - physiology; bone formation; bone repair; Cartilage; Cell Differentiation; Cell Lineage; chemotaxis; Homeostasis - physiology; Humans; Hypoxia-Inducible Factor 1 - genetics; Hypoxia-Inducible Factor 1 - metabolism; Models, Animal; osteoblast recruitment; Osteoblasts - cytology; Osteoblasts - metabolism; Osteogenesis - physiology; osteoprogenitor; Regeneration - physiology; Tissue Engineering; Vascular Endothelial Growth Factor A - metabolism; osteoprogenitor; osteoblast recruitment; bone formation; angiogenesis; bone repair; chemotaxis

During endochondral bone development, bone‐forming osteoblasts have to colonize the regions of cartilage that will be replaced by bone. In adulthood, bone remodeling and repair require osteogenic cells to reach the sites that need to be rebuilt, as a prerequisite for skeletal health. A failure of os...