Acute pulmonary embolism caused by highly aggregated intravenous immunoglobulin

• Published in: Vox sanguinis Vol. 110; no. 1; pp. 27 - 35
• Main Authors: Yu, C. F., Hou, J. F., Shen, L. Z., Gao, K., Rao, C. M., Yang, P. Y., Fu, Z. H., Wang, Q. Z., Li, Y. H., Wang, L., Liu, F., Zhang, L., Qu, Z., Shen, Q., Li, B., Li, X. G., Wang, J. Z.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2016; S. Karger AG
• Subjects: Animals; Blood Coagulation; Coagulation; Embolisms; Haplorhini; Hematology; Humans; Immunoglobulins; Immunoglobulins, Intravenous - adverse effects; Immunoglobulins, Intravenous - therapeutic use; intravenous immunoglobulin; Mice; Mice, Inbred BALB C; Pathogenesis; Proteins; Pulmonary Embolism - etiology; quality control; quality management; Rabbits; Thromboembolism - etiology; quality control; intravenous immunoglobulin; quality management

Background and Objectives Six patients died and one patient survived following infusion of a specific lot of intravenous immunoglobulin (IVIG) within half an hour in May 2008. This study elucidated the underlying pathogenesis. Materials and Methods A variety of protein fractionation and identificati...