Deformability of transfused red blood cells is a potent determinant of transfusion-induced change in recipient's blood flow

• Published in: Microcirculation (New York, N.Y. 1994) Vol. 23; no. 7; pp. 479 - 486
• Main Authors: Barshtein, Gregory, Pries, Axel R., Goldschmidt, Neta, Zukerman, Ayelet, Orbach, Ariel, Zelig, Orly, Arbell, Dan, Yedgar, Saul
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2016; Wiley Subscription Services, Inc
• Subjects: Adult; beta-Thalassemia - blood; beta-Thalassemia - therapy; Blood Flow Velocity; blood transfusion; deformability; Erythrocyte Deformability; Erythrocyte Transfusion - adverse effects; Female; Hematocrit; Humans; Laser-Doppler Flowmetry; Male; microcirculation; Middle Aged; red blood cell; Skin - blood supply; thalassemia patients; blood transfusion; deformability; microcirculation; thalassemia patients; red blood cell

Objective There is a growing concern regarding the risks in the transfusion of PRBC, as numerous studies have reported negative transfusion outcomes, including reduced blood perfusion. In search of this phenomenon's mechanism, the effect of PRBC deformability, a major determinant of blood flow,...