Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery

• Published in: Annals of the New York Academy of Sciences Vol. 1366; no. 1; pp. 61 - 75
• Main Authors: Collier, David A., Eastwood, Brian J., Malki, Karim, Mokrab, Younes
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.02.2016; Wiley Subscription Services, Inc
• Subjects: Antipsychotic Agents - therapeutic use; Biology; drug discovery; Drug Discovery - methods; Drug Discovery - trends; Drugs; Gene Regulatory Networks - genetics; Genes; Genetic Variation - genetics; Genetics; genome-wide association; Genome-Wide Association Study - methods; Genome-Wide Association Study - trends; Humans; Mental disorders; Networks; Pathways; Patients; pharmacogenetics; psychosis; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - drug therapy; Schizophrenia - genetics; genome-wide association; drug discovery; pharmacogenetics; psychosis

The spectacular advance in our understanding of the genetic basis of schizophrenia through genome‐wide association studies has the potential to identify new leads for drug treatment through improved understanding of disease pathophysiology. However, using these genetic associations successfully in d...