Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves

Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano‐ and microscale topogra...

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Published inJournal of biomedical materials research. Part A Vol. 108; no. 5; pp. 1223 - 1230
Main Authors Babakhanova, Greta, Krieger, Jess, Li, Bing‐Xiang, Turiv, Taras, Kim, Min‐Ho, Lavrentovich, Oleg D.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.05.2020
Wiley Subscription Services, Inc
Wiley
Subjects
Alignment
biological cell alignment
Biomedical materials
Coatings
Crystals
Elastic anisotropy
Elastic properties
Elastomers
Etching
Fabrication
Fibroblasts
Fibronectin
Free surfaces
human dermal fibroblast alignment
Human performance
liquid crystal elastomer substrates
MATERIALS SCIENCE
Microprinting
nanotopography
Photopolymerization
Polymers
Smectic liquid crystals
Substrates
Tissue engineering
Topography
human dermal fibroblast alignment
nanotopography
liquid crystal elastomer substrates
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Abstract Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano‐ and microscale topography requires processing by lithography, microprinting, etching, and so forth. In this work, we introduce a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano‐topographies show a high potential for tissue engineering.
AbstractList Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano- and microscale topography requires processing by lithography, microprinting, etching, and so forth. In this work, we introduce a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano-topographies show a high potential for tissue engineering.Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano- and microscale topography requires processing by lithography, microprinting, etching, and so forth. In this work, we introduce a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano-topographies show a high potential for tissue engineering.
Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano‐ and microscale topography requires processing by lithography, microprinting, etching, and so forth. In this work, we introduce a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano‐topographies show a high potential for tissue engineering.
Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers show advantages since they can be tailored by chemical functionalization. Fabrication of polymer substrates with nano- and microscale topography requires processing by lithography, microprinting, etching, etc. In this work, we introduce a different approach based on anisotropic elastic properties of polymerized smectic A (SmA) liquid crystal elastomer (LCE). When the SmA liquid crystal coating is deposited onto a substrate with planar alignment of the molecules, it develops nanogrooves at its free surface. After photopolymerization, these nanogrooves show an excellent ability to align human dermal fibroblasts (hDFs) over large areas. The alignment quality is good for both bare SmA LCE substrates and for substrates coated with fibronectin. The SmA LCE nano-topographies show a high potential for tissue engineering.
Author Li, Bing‐Xiang
Lavrentovich, Oleg D.
Kim, Min‐Ho
Krieger, Jess
Turiv, Taras
Babakhanova, Greta
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  givenname: Jess
  surname: Krieger
  fullname: Krieger, Jess
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  givenname: Bing‐Xiang
  surname: Li
  fullname: Li, Bing‐Xiang
  organization: Kent State University
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  givenname: Taras
  surname: Turiv
  fullname: Turiv, Taras
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  givenname: Min‐Ho
  surname: Kim
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  givenname: Oleg D.
  orcidid: 0000-0002-0128-0708
  surname: Lavrentovich
  fullname: Lavrentovich, Oleg D.
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  organization: Kent State University
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Keywords human dermal fibroblast alignment
nanotopography
liquid crystal elastomer substrates
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Snippet Control of cells behavior through topography of substrates is an important theme in biomedical applications. Among many materials used as substrates, polymers...
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SubjectTerms Alignment
biological cell alignment
Biomedical materials
Coatings
Crystals
Elastic anisotropy
Elastic properties
Elastomers
Etching
Fabrication
Fibroblasts
Fibronectin
Free surfaces
human dermal fibroblast alignment
Human performance
liquid crystal elastomer substrates
MATERIALS SCIENCE
Microprinting
nanotopography
Photopolymerization
Polymers
Smectic liquid crystals
Substrates
Tissue engineering
Topography
Title Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbm.a.36896
https://www.ncbi.nlm.nih.gov/pubmed/32034939
https://www.proquest.com/docview/2377825932
https://www.proquest.com/docview/2352657828
https://www.osti.gov/servlets/purl/1597484
Volume 108
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