Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer
BACKGROUND Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS Imm...
Saved in:
| Published in | The Prostate Vol. 67; no. 4; pp. 348 - 360 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.03.2007
Wiley-Liss |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | BACKGROUND
Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa.
METHODS
Immunohistochemistry, in vitro co‐culture, cell migration, and attachment assays.
RESULTS
hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co‐cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co‐culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4‐transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone‐matrix proteins, collagens I and IV.
CONCLUSIONS
hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established. Prostate 67: 348–360, 2007. © 2007 Wiley‐Liss, Inc. |
|---|---|
| AbstractList | BACKGROUNDProstate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa.METHODSImmunohistochemistry, in vitro co-culture, cell migration, and attachment assays.RESULTShK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV.CONCLUSIONShK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established. Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established. Abstract BACKGROUND Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 ( KLK4 /hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4 /hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS Immunohistochemistry, in vitro co‐culture, cell migration, and attachment assays. RESULTS hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4 /hK4 increased in LNCaP and PC3 cells co‐cultured with SaOs2 cells; SaOs2 KLK4 /hK4 was unchanged. Co‐culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4 ‐transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone‐matrix proteins, collagens I and IV. CONCLUSIONS hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established. Prostate 67: 348–360, 2007. © 2007 Wiley‐Liss, Inc. BACKGROUND Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS Immunohistochemistry, in vitro co‐culture, cell migration, and attachment assays. RESULTS hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co‐cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co‐culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4‐transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone‐matrix proteins, collagens I and IV. CONCLUSIONS hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established. Prostate 67: 348–360, 2007. © 2007 Wiley‐Liss, Inc. |
| Author | Bui, Loan Herington, Adrian C. Gao, Jin Clements, Judith A. Nicol, David L. Collard, Rachael L. |
| Author_xml | – sequence: 1 givenname: Jin surname: Gao fullname: Gao, Jin organization: Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia – sequence: 2 givenname: Rachael L. surname: Collard fullname: Collard, Rachael L. organization: Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia – sequence: 3 givenname: Loan surname: Bui fullname: Bui, Loan organization: Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia – sequence: 4 givenname: Adrian C. surname: Herington fullname: Herington, Adrian C. organization: Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia – sequence: 5 givenname: David L. surname: Nicol fullname: Nicol, David L. organization: Department of Urology, Princess Alexandra Hospital, Brisbane, Australia – sequence: 6 givenname: Judith A. surname: Clements fullname: Clements, Judith A. email: j.clements@qut.edu.au organization: Prostate Cancer Research Program, School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18554447$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17221837$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kD9vFDEQxS0URC6Bhg-A3EARaYPttdfnkkQkIEIS8UcprVnfrGTi8x62TyEdHx1vbiEd1Uzxe2_mvQOyF8eIhLzk7JgzJt5u0piPBZOdekIWnBndMCbVHlkwoVkjeav3yUHOPxirOBPPyD7XQvBlqxfk9ycIwd8m9JFK6jMFuhkLxuIh0DWuPJQx0XGgDkPYBkjUx4IJXPFjzLTHcocYqYPoMD1A1SKu6JgLjn2AXHJVVKdSVyje0enbuuGseU6eDhAyvpjnIfl-9v7b6Yfm4ur84-m7i8bJjqvGKMM4oDKmxU5L41pYqVYJpnreS9mJgcmazjg3dAI5h071RrUOauDahmkPyZudb73_c4u52LXP078Qcdxm2y2NNowtK3i0A119NCcc7Cb5NaR7y5md-rZTAvvQd4Vfza7bvrb1iM4FV-D1DEB2EIZUQ_v8yC2VklJOHN9xdz7g_X9O2usvV1__Hm92Gl_L_vVPA-nWdrrVyt5cnlv-WZ-c8JtLe93-ASkEqb8 |
| CODEN | PRSTDS |
| CitedBy_id | crossref_primary_10_1002_pros_21395 crossref_primary_10_1074_jbc_M109_013623 crossref_primary_10_1074_jbc_R109_027946 crossref_primary_10_1074_jbc_M709493200 crossref_primary_10_1517_14728222_2014_880693 crossref_primary_10_3390_cancers12123501 crossref_primary_10_1021_acs_jproteome_5b01148 crossref_primary_10_1016_j_chembiol_2009_05_008 crossref_primary_10_1016_j_snb_2020_128788 crossref_primary_10_1517_14728222_2016_1147560 crossref_primary_10_1097_PAT_0b013e3283513f3b crossref_primary_10_1517_13543784_2015_1035708 crossref_primary_10_1002_hed_21496 crossref_primary_10_1007_s10555_019_09815_3 crossref_primary_10_1158_0008_5472_CAN_10_2646 crossref_primary_10_1016_j_urolonc_2008_06_002 crossref_primary_10_1016_j_mednuc_2007_10_008 crossref_primary_10_1210_er_2009_0034 crossref_primary_10_1002_1878_0261_12075 crossref_primary_10_1261_rna_2019810 crossref_primary_10_1016_j_neo_2019_07_010 crossref_primary_10_1038_s41568_021_00436_z crossref_primary_10_1002_cbin_10736 crossref_primary_10_1002_jgm_3372 crossref_primary_10_1002_bies_20676 crossref_primary_10_1111_j_1742_4658_2008_06265_x crossref_primary_10_1158_1541_7786_MCR_08_0096 crossref_primary_10_1016_j_intimp_2007_08_003 crossref_primary_10_1038_nrd4534 crossref_primary_10_1371_journal_pone_0019302 crossref_primary_10_1021_acsmedchemlett_8b00422 crossref_primary_10_2217_fon_09_149 crossref_primary_10_1016_j_bone_2014_02_001 crossref_primary_10_1002_pros_22667 crossref_primary_10_1007_s13577_015_0114_6 crossref_primary_10_1016_j_biochi_2015_09_023 crossref_primary_10_1016_j_biochi_2015_09_002 crossref_primary_10_1111_IGC_0b013e3181a83e1a |
| Cites_doi | 10.1034/j.1600-0722.2002.21301.x 10.1097/00042307-200109000-00006 10.1016/S0378-1119(00)00203-1 10.1158/0008-5472.CAN-04-1660 10.1097/01.ju.0000141582.15218.10 10.1074/jbc.M004525200 10.1016/S0046-8177(03)00190-4 10.1002/(SICI)1097-4644(19960401)61:1<18::AID-JCB3>3.0.CO;2-5 10.1016/j.bbrc.2004.11.162 10.1177/00220345980770020601 10.1080/10408360490471931 10.1038/nrc867 10.1002/(SICI)1097-0045(19990501)39:2<108::AID-PROS5>3.0.CO;2-9 10.1002/pros.10186 10.1200/JCO.2002.20.3.833 10.1038/nrc1474 10.1007/978-1-4419-9129-4_8 10.1002/jcb.1211 10.1677/erc.1.00958 10.1002/pros.10091 10.1002/pros.1075 10.1074/jbc.274.33.23210 10.1073/pnas.96.6.3114 10.1093/clinchem/48.8.1232 10.1016/0022-1759(83)90303-4 10.1002/pros.10088 10.1038/nrc1528 10.1006/bbrc.1993.1506 10.1080/10408369891234219 10.1902/jop.1999.70.9.951 10.1016/S1043-2760(99)00225-8 10.1089/104454901750361497 10.1021/bi015775e 10.1002/pros.20101 10.1248/bpb.20.345 10.1002/ijc.1501 10.1006/geno.2000.6490 10.1016/S0022-1759(03)00223-0 10.1158/0008-5472.CAN-03-2025 |
| ContentType | Journal Article |
| Copyright | Copyright © 2007 Wiley‐Liss, Inc. 2007 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2007 Wiley‐Liss, Inc. – notice: 2007 INIST-CNRS |
| DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1002/pros.20465 |
| DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-0045 |
| EndPage | 360 |
| ExternalDocumentID | 10_1002_pros_20465 17221837 18554447 PROS20465 ark_67375_WNG_1M7BB1WN_P |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Queensland Cancer Fund PhD Scholarship – fundername: NHMRC Peter Doherty Post‐doctoral Fellowship – fundername: National Health and Medical Research Council (NHMRC) of Australia funderid: 101202 – fundername: Queensland Cancer Foundation |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABIJN ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 QRW R.K ROL RWI RX1 RYL SUPJJ TEORI UB1 V2E W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WWO WXI WXSBR XG1 XV2 ZZTAW ~IA ~WT .GJ 3O- AAVGM ABEML ABHUG ABWRO ACSCC ACXME ADAWD ADDAD AFVGU AGJLS EBD EMOBN HF~ IQODW M6P PALCI RIWAO RJQFR SAMSI SV3 ZA5 ZGI ZXP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c4615-95901ae5993e6749c3ad535205b1b4462f041009ccf62e11a65b953ca00200493 |
| IEDL.DBID | DR2 |
| ISSN | 0270-4137 |
| IngestDate | Fri Aug 16 21:07:18 EDT 2024 Fri Aug 23 02:11:29 EDT 2024 Sat Sep 28 07:57:41 EDT 2024 Sun Oct 22 16:07:27 EDT 2023 Sat Aug 24 01:14:24 EDT 2024 Wed Oct 30 09:55:19 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Andrology Nephrology Vasodilator agent Prostate disease Diseases of the osteoarticular system co-culture Osteoarticular system Mixed cell culture Plasma kallikrein Osteoblast Advanced stage osteoblasts Male genital diseases Tumor cell Urinary system disease Serine endopeptidases Enzyme Gynecology Interaction Malignant tumor Peptidases Bone metastasis prostatic kallikreins Hydrolases Mediator Metastatic Bone Prostate cancer |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4615-95901ae5993e6749c3ad535205b1b4462f041009ccf62e11a65b953ca00200493 |
| Notes | National Health and Medical Research Council (NHMRC) of Australia - No. 101202 Queensland Cancer Foundation ArticleID:PROS20465 NHMRC Peter Doherty Post-doctoral Fellowship istex:9A6ABA2CE7C0302DE614DBD63C564A8561DE729B ark:/67375/WNG-1M7BB1WN-P Queensland Cancer Fund PhD Scholarship Jin Gao and Rachael L. Collard contributed equally to the work as first authors. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 17221837 |
| PQID | 68979008 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_68979008 crossref_primary_10_1002_pros_20465 pubmed_primary_17221837 pascalfrancis_primary_18554447 wiley_primary_10_1002_pros_20465_PROS20465 istex_primary_ark_67375_WNG_1M7BB1WN_P |
| PublicationCentury | 2000 |
| PublicationDate | 1 March 2007 |
| PublicationDateYYYYMMDD | 2007-03-01 |
| PublicationDate_xml | – month: 03 year: 2007 text: 1 March 2007 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken – name: New York, NY – name: United States |
| PublicationTitle | The Prostate |
| PublicationTitleAlternate | Prostate |
| PublicationYear | 2007 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company Wiley-Liss |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company – name: Wiley-Liss |
| References | Harvey TJ, Hooper JD, Myers SA, et al. Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem 2000; 275: 37397-37406. Saito K, Oku T, Ata N, et al. A modified and convenient method for assessing tumor cell invasion and migration and its application to screening for inhibitors. Biol Pharm Bull 1997; 20: 345-348. Juretic N, Santibanez JF, Hurtado C, Martinez J. ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line. J Cell Biochem 2001; 83: 92-98. Nelson PS, Gan L, Ferguson C, et al. Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc Natl Acad Sci USA 1999; 96: 3114-3119. Clements JA, Willemsen NM, Myers SA, Dong Y. The tissue kallikrein family of serine proteases: Functional roles in human disease and potential as clinical biomarkers. Crit Rev Clin Lab Sci 2004; 41: 265-312. Mundy GR. Metastasis to bone: Causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002; 2: 584-593. Rittenhouse HG, Finlay JA, Mikolajczyk SD, Partin AW. Human Kallikrein 2 (hK2) and prostate-specific antigen (PSA): Two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci 1998; 35: 275-368. Killian CS, Corral DA, Kawinski E, Constantine RI. Mitogenic response of osteoblast cells to prostate-specific antigen suggests an activation of latent TGF-beta and a proteolytic modulation of cell adhesion receptors. Biochem Biophys Res Commun 1993; 192: 940-947. Fizazi K, Sikes CR, Kim J, et al. High efficacy of docetaxel with and without androgen deprivation and estramustine in preclinical models of advanced prostate cancer. Anticancer Res 2004; 24: 2897-2903. Hu JC, Zhang C, Sun X, et al. Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. Gene 2000; 251: 1-8. Saedi MS, Zhu Z, Marker K, et al. Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells. Int J Cancer 2001; 94: 558-563. Simmer JP, Bartlett JD. Kallikrein 4 is a secreted protein. Cancer Res 2004; 64: 8481-8482; author reply 8482-8483. Yang J, Fizazi K, Peleg S, et al. Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway. Cancer Res 2001; 61: 5652-5659. Bonfil RD, Osenkowski P, Fridman R, Cher ML. Matrix metalloproteinaes and bone metastasis. Cancer Treat Res 2004; 118: 173-195. Jacob K, Webber M, Benayahu D, Kleinman HK. Osteonectin promotes prostate cancer cell migration and invasion: A possible mechanism for metastasis to bone. Cancer Res 1999; 59: 4453-4457. Romanov VI, Goligorsky MS. RGD-recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro. Prostate 1999; 39: 108-118. Pinski J, Parikh A, Bova GS, Isaacs JT. Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts. Cancer Res 2001; 61: 6372-6376. Chung LW, Baseman A, Assikis V, Zhau HE. Molecular insights into prostate cancer progression: The missing link of tumor microenvironment. J Urol 2005; 173: 10-20. Lang SH, Hyde C, Reid IN, et al. Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma. Prostate 2002; 52: 253-263. Roudier MP, True LD, Higano CS, et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. Hum Pathol 2003; 34: 646-653. Nemeth JA, Harb JF, Barroso U, Jr., et al. Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res 1999; 59: 1987-1993. Hu JC, Sun X, Zhang C, et al. Enamelysin and kallikrein-4 mRNA expression in developing mouse molars. Eur J Oral Sci 2002; 110: 307-315. Obiezu CV, Soosaipillai A, Jung K, et al. Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry. Clin Chem 2002; 48: 1232-1240. Denmeade SR, Sokoll LJ, Chan DW, Khan SR, Isaacs JT. Concentration of enzymatically active prostate-specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models. Prostate 2001; 48: 1-6. Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV. The new human kallikrein gene family: Implications in carcinogenesis. Trends Endocrinol Metab 2000; 11: 54-60. Korkmaz KS, Korkmaz CG, Pretlow TG, Saatcioglu F. Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the kallikrein family: Intracellular localization, alternative cDNA forms, and regulation by multiple hormones. DNA Cell Biol 2001; 20: 435-445. Matsumura M, Bhatt AS, Andress D, et al. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate 2005; 62: 1-13. Scorilas A, Plebani M, Mazza S, et al. Serum human glandular kallikrein (hK2) and insulin-like growth factor 1 (IGF-1) improve the discrimination between prostate cancer and benign prostatic hyperplasia in combination with total and %free PSA. Prostate 2003; 54: 220-229. Deftos LJ, Barken I, Burton DW, Hoffman RM, Geller J. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem Biophys Res Commun 2005; 327: 468-472. Yousef GM, Obiezu CV, Luo LY, Black MH, Diamandis EP. Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. Cancer Res 1999; 59: 4252-4256. Corey E, Quinn JE, Bladou F, et al. Establishment and characterization of osseous prostate cancer models: Intra-tibial injection of human prostate cancer cells. Prostate 2002; 52: 20-33. Takayama TK, McMullen BA, Nelson PS, Matsumura M, Fujikawa K. Characterization of hK4 (prostase), a prostate-specific serine protease: Activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry 2001; 40: 15341-15348. Whelan JA, Russell NB, Whelan MA. A method for the absolute quantification of cDNA using real-time PCR. J Immunol Methods 2003; 278: 261-269. Harvey TJ, Dong Y, Bui L, et al. Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to Kallikrein 4. Methods Mol Med 2003; 81: 241-254. Veveris-Lowe TL, Lawrence MG, Collard RL, Bui LT, Herington AC, Nicol D, Clements JA. Kallikrein 4 (hK4) and Prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr Relat Cancer 2005; 12: 617-629. Cher ML. Mechanisms governing bone metastasis in prostate cancer. Curr Opin Urol 2001; 11: 483-488. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63. Logothetis CJ, Lin SH. Osteoblasts in prostate cancer metastasis to bone. Nat Rev Cancer 2005; 5: 21-28. Stephenson SA, Verity K, Ashworth LK, Clements JA. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J Biol Chem 1999; 274: 23210-23214. Simmer JP, Fukae M, Tanabe T, et al. Purification, characterization, and cloning of enamel matrix serine proteinase 1. J Dent Res 1998; 77: 377-386. Martinez J, Silva S, Santibanez JF. Prostate-derived soluble factors block osteoblast differentiation in culture. J Cell Biochem 1996; 61: 18-25. Shariat SF, Lamb DJ, Kattan MW, et al. Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis. J Clin Oncol 2002; 20: 833-841. Borgono CA, Diamandis EP. The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer 2004; 4: 876-890. Hooper JD, Bui LT, Rae FK, et al. Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle. Genomics 2001; 73: 117-122. Gao J, Symons AL, Haase H, Bartold PM. Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro. J Periodontol 1999; 70: 951-959. Xi Z, Klokk TI, Korkmaz K, et al. Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer. Cancer Res 2004; 64: 2365-2370. 2004; 41 2001; 94 2004; 64 2005; 173 2003; 81 2002; 52 2002; 110 1997; 20 2004; 24 2004; 4 2005; 62 2002; 2 2000; 251 2001; 48 2000; 275 2003; 278 2001; 40 2003; 54 2001; 20 2003; 34 2002; 48 2001; 61 2001; 83 2002; 20 1999; 39 2000; 11 1999; 59 2005; 5 2005; 327 1999; 274 1996; 61 1983; 65 1999; 96 1993; 192 2001; 11 1999; 70 2004; 118 2001; 73 1998; 77 2005; 12 1998; 35 Yousef GM (e_1_2_1_21_2) 1999; 59 Pinski J (e_1_2_1_41_2) 2001; 61 Jacob K (e_1_2_1_40_2) 1999; 59 Obiezu CV (e_1_2_1_23_2) 2002; 48 Harvey TJ (e_1_2_1_26_2) 2003; 81 e_1_2_1_22_2 e_1_2_1_45_2 e_1_2_1_44_2 e_1_2_1_20_2 e_1_2_1_43_2 e_1_2_1_42_2 e_1_2_1_27_2 e_1_2_1_24_2 e_1_2_1_47_2 e_1_2_1_25_2 e_1_2_1_46_2 Yang J (e_1_2_1_36_2) 2001; 61 e_1_2_1_29_2 Nemeth JA (e_1_2_1_28_2) 1999; 59 e_1_2_1_6_2 e_1_2_1_30_2 e_1_2_1_7_2 e_1_2_1_4_2 e_1_2_1_5_2 e_1_2_1_2_2 e_1_2_1_11_2 e_1_2_1_34_2 e_1_2_1_3_2 e_1_2_1_12_2 e_1_2_1_33_2 e_1_2_1_32_2 e_1_2_1_10_2 e_1_2_1_31_2 e_1_2_1_15_2 e_1_2_1_16_2 e_1_2_1_37_2 e_1_2_1_13_2 e_1_2_1_14_2 e_1_2_1_35_2 Fizazi K (e_1_2_1_38_2) 2004; 24 e_1_2_1_19_2 e_1_2_1_8_2 e_1_2_1_17_2 e_1_2_1_9_2 e_1_2_1_18_2 e_1_2_1_39_2 |
| References_xml | – volume: 61 start-page: 5652 year: 2001 end-page: 5659 article-title: Prostate cancer cells induce osteoblast differentiation through a Cbfa1‐dependent pathway publication-title: Cancer Res – volume: 39 start-page: 108 year: 1999 end-page: 118 article-title: RGD‐recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro publication-title: Prostate – volume: 96 start-page: 3114 year: 1999 end-page: 3119 article-title: Molecular cloning and characterization of prostase, an androgen‐regulated serine protease with prostate‐restricted expression publication-title: Proc Natl Acad Sci USA – volume: 61 start-page: 6372 year: 2001 end-page: 6376 article-title: Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts publication-title: Cancer Res – volume: 118 start-page: 173 year: 2004 end-page: 195 article-title: Matrix metalloproteinaes and bone metastasis publication-title: Cancer Treat Res – volume: 59 start-page: 1987 year: 1999 end-page: 1993 article-title: Severe combined immunodeficient‐hu model of human prostate cancer metastasis to human bone publication-title: Cancer Res – volume: 62 start-page: 1 year: 2005 end-page: 13 article-title: Substrates of the prostate‐specific serine protease prostase/KLK4 defined by positional‐scanning peptide libraries publication-title: Prostate – volume: 4 start-page: 876 year: 2004 end-page: 890 article-title: The emerging roles of human tissue kallikreins in cancer publication-title: Nat Rev Cancer – volume: 35 start-page: 275 year: 1998 end-page: 368 article-title: Human Kallikrein 2 (hK2) and prostate‐specific antigen (PSA): Two closely related, but distinct, kallikreins in the prostate publication-title: Crit Rev Clin Lab Sci – volume: 275 start-page: 37397 year: 2000 end-page: 37406 article-title: Tissue‐specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4 publication-title: J Biol Chem – volume: 59 start-page: 4252 year: 1999 end-page: 4256 article-title: Prostase/KLK‐L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated publication-title: Cancer Res – volume: 41 start-page: 265 year: 2004 end-page: 312 article-title: The tissue kallikrein family of serine proteases: Functional roles in human disease and potential as clinical biomarkers publication-title: Crit Rev Clin Lab Sci – volume: 11 start-page: 483 year: 2001 end-page: 488 article-title: Mechanisms governing bone metastasis in prostate cancer publication-title: Curr Opin Urol – volume: 20 start-page: 833 year: 2002 end-page: 841 article-title: Association of preoperative plasma levels of insulin‐like growth factor I and insulin‐like growth factor binding proteins‐2 and ‐3 with prostate cancer invasion, progression, and metastasis publication-title: J Clin Oncol – volume: 2 start-page: 584 year: 2002 end-page: 593 article-title: Metastasis to bone: Causes, consequences and therapeutic opportunities publication-title: Nat Rev Cancer – volume: 5 start-page: 21 year: 2005 end-page: 28 article-title: Osteoblasts in prostate cancer metastasis to bone publication-title: Nat Rev Cancer – volume: 110 start-page: 307 year: 2002 end-page: 315 article-title: Enamelysin and kallikrein‐4 mRNA expression in developing mouse molars publication-title: Eur J Oral Sci – volume: 12 start-page: 617 year: 2005 end-page: 629 article-title: Kallikrein 4 (hK4) and Prostate‐specific antigen (PSA) are associated with the loss of E‐cadherin and an epithelial‐mesenchymal transition (EMT)‐like effect in prostate cancer cells publication-title: Endocr Relat Cancer – volume: 70 start-page: 951 year: 1999 end-page: 959 article-title: Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro publication-title: J Periodontol – volume: 278 start-page: 261 year: 2003 end-page: 269 article-title: A method for the absolute quantification of cDNA using real‐time PCR publication-title: J Immunol Methods – volume: 94 start-page: 558 year: 2001 end-page: 563 article-title: Human kallikrein 2 (hK2), but not prostate‐specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI‐6) released from prostate carcinoma cells publication-title: Int J Cancer – volume: 52 start-page: 253 year: 2002 end-page: 263 article-title: Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma publication-title: Prostate – volume: 65 start-page: 55 year: 1983 end-page: 63 article-title: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays publication-title: J Immunol Methods – volume: 48 start-page: 1 year: 2001 end-page: 6 article-title: Concentration of enzymatically active prostate‐specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models publication-title: Prostate – volume: 54 start-page: 220 year: 2003 end-page: 229 article-title: Serum human glandular kallikrein (hK2) and insulin‐like growth factor 1 (IGF‐1) improve the discrimination between prostate cancer and benign prostatic hyperplasia in combination with total and %free PSA publication-title: Prostate – volume: 48 start-page: 1232 year: 2002 end-page: 1240 article-title: Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry publication-title: Clin Chem – volume: 61 start-page: 18 year: 1996 end-page: 25 article-title: Prostate‐derived soluble factors block osteoblast differentiation in culture publication-title: J Cell Biochem – volume: 83 start-page: 92 year: 2001 end-page: 98 article-title: ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS‐2 cell line publication-title: J Cell Biochem – volume: 73 start-page: 117 year: 2001 end-page: 122 article-title: Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle publication-title: Genomics – volume: 64 start-page: 8481 year: 2004 end-page: 8482 article-title: Kallikrein 4 is a secreted protein publication-title: Cancer Res – volume: 11 start-page: 54 year: 2000 end-page: 60 article-title: The new human kallikrein gene family: Implications in carcinogenesis publication-title: Trends Endocrinol Metab – volume: 34 start-page: 646 year: 2003 end-page: 653 article-title: Phenotypic heterogeneity of end‐stage prostate carcinoma metastatic to bone publication-title: Hum Pathol – volume: 20 start-page: 435 year: 2001 end-page: 445 article-title: Distinctly different gene structure of KLK4/KLK‐L1/prostase/ARM1 compared with other members of the kallikrein family: Intracellular localization, alternative cDNA forms, and regulation by multiple hormones publication-title: DNA Cell Biol – volume: 173 start-page: 10 year: 2005 end-page: 20 article-title: Molecular insights into prostate cancer progression: The missing link of tumor microenvironment publication-title: J Urol – volume: 251 start-page: 1 year: 2000 end-page: 8 article-title: Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors publication-title: Gene – volume: 59 start-page: 4453 year: 1999 end-page: 4457 article-title: Osteonectin promotes prostate cancer cell migration and invasion: A possible mechanism for metastasis to bone publication-title: Cancer Res – volume: 81 start-page: 241 year: 2003 end-page: 254 article-title: Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to Kallikrein 4 publication-title: Methods Mol Med – volume: 20 start-page: 345 year: 1997 end-page: 348 article-title: A modified and convenient method for assessing tumor cell invasion and migration and its application to screening for inhibitors publication-title: Biol Pharm Bull – volume: 274 start-page: 23210 year: 1999 end-page: 23214 article-title: Localization of a new prostate‐specific antigen‐related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3‐13.4 publication-title: J Biol Chem – volume: 192 start-page: 940 year: 1993 end-page: 947 article-title: Mitogenic response of osteoblast cells to prostate‐specific antigen suggests an activation of latent TGF‐beta and a proteolytic modulation of cell adhesion receptors publication-title: Biochem Biophys Res Commun – volume: 52 start-page: 20 year: 2002 end-page: 33 article-title: Establishment and characterization of osseous prostate cancer models: Intra‐tibial injection of human prostate cancer cells publication-title: Prostate – volume: 327 start-page: 468 year: 2005 end-page: 472 article-title: Direct evidence that PTHrP expression promotes prostate cancer progression in bone publication-title: Biochem Biophys Res Commun – volume: 77 start-page: 377 year: 1998 end-page: 386 article-title: Purification, characterization, and cloning of enamel matrix serine proteinase 1 publication-title: J Dent Res – volume: 24 start-page: 2897 year: 2004 end-page: 2903 article-title: High efficacy of docetaxel with and without androgen deprivation and estramustine in preclinical models of advanced prostate cancer publication-title: Anticancer Res – volume: 64 start-page: 2365 year: 2004 end-page: 2370 article-title: Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer publication-title: Cancer Res – volume: 40 start-page: 15341 year: 2001 end-page: 15348 article-title: Characterization of hK4 (prostase), a prostate‐specific serine protease: Activation of the precursor of prostate specific antigen (pro‐PSA) and single‐chain urokinase‐type plasminogen activator and degradation of prostatic acid phosphatase publication-title: Biochemistry – ident: e_1_2_1_22_2 doi: 10.1034/j.1600-0722.2002.21301.x – ident: e_1_2_1_3_2 doi: 10.1097/00042307-200109000-00006 – volume: 24 start-page: 2897 year: 2004 ident: e_1_2_1_38_2 article-title: High efficacy of docetaxel with and without androgen deprivation and estramustine in preclinical models of advanced prostate cancer publication-title: Anticancer Res contributor: fullname: Fizazi K – ident: e_1_2_1_20_2 doi: 10.1016/S0378-1119(00)00203-1 – ident: e_1_2_1_45_2 doi: 10.1158/0008-5472.CAN-04-1660 – ident: e_1_2_1_5_2 doi: 10.1097/01.ju.0000141582.15218.10 – volume: 61 start-page: 6372 year: 2001 ident: e_1_2_1_41_2 article-title: Therapeutic implications of enhanced G(0)/G(1) checkpoint control induced by coculture of prostate cancer cells with osteoblasts publication-title: Cancer Res contributor: fullname: Pinski J – ident: e_1_2_1_8_2 doi: 10.1074/jbc.M004525200 – ident: e_1_2_1_2_2 doi: 10.1016/S0046-8177(03)00190-4 – ident: e_1_2_1_42_2 doi: 10.1002/(SICI)1097-4644(19960401)61:1<18::AID-JCB3>3.0.CO;2-5 – ident: e_1_2_1_15_2 doi: 10.1016/j.bbrc.2004.11.162 – ident: e_1_2_1_19_2 doi: 10.1177/00220345980770020601 – ident: e_1_2_1_9_2 doi: 10.1080/10408360490471931 – ident: e_1_2_1_4_2 doi: 10.1038/nrc867 – ident: e_1_2_1_34_2 doi: 10.1002/(SICI)1097-0045(19990501)39:2<108::AID-PROS5>3.0.CO;2-9 – ident: e_1_2_1_11_2 doi: 10.1002/pros.10186 – ident: e_1_2_1_16_2 doi: 10.1200/JCO.2002.20.3.833 – ident: e_1_2_1_10_2 doi: 10.1038/nrc1474 – volume: 59 start-page: 4453 year: 1999 ident: e_1_2_1_40_2 article-title: Osteonectin promotes prostate cancer cell migration and invasion: A possible mechanism for metastasis to bone publication-title: Cancer Res contributor: fullname: Jacob K – ident: e_1_2_1_46_2 doi: 10.1007/978-1-4419-9129-4_8 – ident: e_1_2_1_39_2 doi: 10.1002/jcb.1211 – ident: e_1_2_1_27_2 doi: 10.1677/erc.1.00958 – ident: e_1_2_1_37_2 doi: 10.1002/pros.10091 – volume: 59 start-page: 4252 year: 1999 ident: e_1_2_1_21_2 article-title: Prostase/KLK‐L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated publication-title: Cancer Res contributor: fullname: Yousef GM – ident: e_1_2_1_47_2 doi: 10.1002/pros.1075 – ident: e_1_2_1_17_2 doi: 10.1074/jbc.274.33.23210 – ident: e_1_2_1_18_2 doi: 10.1073/pnas.96.6.3114 – volume: 48 start-page: 1232 year: 2002 ident: e_1_2_1_23_2 article-title: Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry publication-title: Clin Chem doi: 10.1093/clinchem/48.8.1232 contributor: fullname: Obiezu CV – ident: e_1_2_1_30_2 doi: 10.1016/0022-1759(83)90303-4 – ident: e_1_2_1_29_2 doi: 10.1002/pros.10088 – ident: e_1_2_1_6_2 doi: 10.1038/nrc1528 – ident: e_1_2_1_13_2 doi: 10.1006/bbrc.1993.1506 – volume: 81 start-page: 241 year: 2003 ident: e_1_2_1_26_2 article-title: Production and characterization of antipeptide kallikrein 4 antibodies. Use of computer modeling to design peptides specific to Kallikrein 4 publication-title: Methods Mol Med contributor: fullname: Harvey TJ – ident: e_1_2_1_14_2 doi: 10.1080/10408369891234219 – ident: e_1_2_1_31_2 doi: 10.1902/jop.1999.70.9.951 – ident: e_1_2_1_7_2 doi: 10.1016/S1043-2760(99)00225-8 – volume: 59 start-page: 1987 year: 1999 ident: e_1_2_1_28_2 article-title: Severe combined immunodeficient‐hu model of human prostate cancer metastasis to human bone publication-title: Cancer Res contributor: fullname: Nemeth JA – ident: e_1_2_1_43_2 doi: 10.1089/104454901750361497 – ident: e_1_2_1_24_2 doi: 10.1021/bi015775e – ident: e_1_2_1_25_2 doi: 10.1002/pros.20101 – ident: e_1_2_1_33_2 doi: 10.1248/bpb.20.345 – ident: e_1_2_1_35_2 doi: 10.1002/ijc.1501 – ident: e_1_2_1_12_2 doi: 10.1006/geno.2000.6490 – ident: e_1_2_1_32_2 doi: 10.1016/S0022-1759(03)00223-0 – volume: 61 start-page: 5652 year: 2001 ident: e_1_2_1_36_2 article-title: Prostate cancer cells induce osteoblast differentiation through a Cbfa1‐dependent pathway publication-title: Cancer Res contributor: fullname: Yang J – ident: e_1_2_1_44_2 doi: 10.1158/0008-5472.CAN-03-2025 |
| SSID | ssj0010002 |
| Score | 2.100668 |
| Snippet | BACKGROUND
Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and... Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized... Abstract BACKGROUND Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 ( KLK4 /hK4) is expressed in both PCa... BACKGROUNDProstate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and... |
| SourceID | proquest crossref pubmed pascalfrancis wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 348 |
| SubjectTerms | Biological and medical sciences bone metastasis Bone Neoplasms - metabolism Bone Neoplasms - secondary Cell Adhesion - physiology Cell Communication - physiology Cell Line, Tumor Cell Movement - physiology co-culture Coculture Techniques Gynecology. Andrology. Obstetrics Humans Kallikreins - genetics Kallikreins - metabolism Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases osteoblasts Osteoblasts - cytology Osteoblasts - metabolism prostate cancer Prostate-Specific Antigen - metabolism prostatic kallikreins Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RNA, Messenger - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| Title | Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer |
| URI | https://api.istex.fr/ark:/67375/WNG-1M7BB1WN-P/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpros.20465 https://www.ncbi.nlm.nih.gov/pubmed/17221837 https://search.proquest.com/docview/68979008 |
| Volume | 67 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PaxQxFH6UCuJFrb86amtA8SBMu5NJJjvgxbbWonQt1dJeJCSZDCxbZsrMLIgn_3Tfy8zusiKC3uaQF_LjvcyX5HtfAF6psZXcj22cm1LFhMlj45WMRebSwnrjiyIQZCfZyYX4eCWvNuDtIhem14dYHrhRZIT1mgLc2HZ_JRqKCwzJbYuMMsyTVBGf6-h8qR1F59bhCoGrUYwrtVpqk_L9lena3-gWDex3YkeaFgeo7F-2-BP0XEey4Vd0fA--LTrRM1Bme_PO7rkfv-k7_m8v78PdAaOyd71TbcGGrx7A7dPhFv4h_Pxkrq-ns8ZPKybYtGWG3dQd0Y7QKqSi4Eae1SWjWwGiuTISpWj6FIqWDdQw5sjhmlAIq6gKRvkmtUU437VogTV1hvKdpo5R-wgVDzaP4OL4_dfDk3h4ySF2AiFTnFOGq_ESwZDPlMhdagrSlRlJm1jckPJyJLDDuXNlxn2SmEzaXKbOEJrFPUz6GDaruvLbwDIjrOEjX3pvEYxw66QoSUat4OhfpY3g5WJG9U0v2KF7aWauqbE6DGYEr8NkL4uYZkYUNyX15eSDTk7VwUFyOdFnEeyuecOqTuL3CaEieLFwD42RSWNmKl_PW52Nc5UjxIrgSe81K1vFCZmi7Zsw939pqD47__wlfD39l8LP4E5_CE1kueew2TVzv4PoqbO7IUp-AXBqFyY |
| link.rule.ids | 315,783,787,1378,27936,27937,46306,46730 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWglYAL34XQ0loCcUBKu3HseHOkhbLQ7lKVVu3Nsh1HWm2VVElWQpz46Z2x010tQkhwy8FjOfaM_Wy_eSbkrRwawdzQxLkuZYyYPNZOiphnNi2M064oPEF2ko3O-ddLcdlzczAXJuhDLA7cMDL8fI0BjgfSe0vVUJhhUG-bZ-IuWYd4T_Hlho-nC_UoPLn2lwhMDmKYq-VCnZTtLW1X1qN17NofyI_ULXRRGd62-BP4XMWyfjE6fBReXG29hiFyUGa7887s2p-_KTz-938-Jg97mEo_BL96Qu646im5N-4v4p-RX0f66mo6a9y0opxOW6rpdd0h8wisfDYK7OVpXVK8GECmK0VdiiZkUbS0Z4dRiz7X-EJQRVVQTDmpDSD6rgULqKnTmPI0tRTbh8C4t3lOzg8_nR2M4v4xh9hyQE1xjkmu2gnAQy6TPLepLlBaZiBMYmBPysoBhx_OrS0z5pJEZ8LkIrUaAS1sY9INslbVlXtJaKa50WzgSucM4BFmrOAlKqkVDFysNBF5czuk6jpodqigzswUNlb5zozIOz_aiyK6mSHLTQp1MfmskrHc308uJuokItsr7rCsEyl-nMuI7Nz6h4LgxD7TlavnrcqGucwBZUXkRXCbpa1kCE7B9r0f_L80VJ2cfvvuv179S-Edcn90Nj5Wx18mR5vkQTiTRu7cFlnrmrl7DWCqM9s-ZG4AvEQbPg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VVqq48H6ER2sJxAEp7cZrxxuJCwWWQumyKlTtBVm240irrZJVkpUQJ346M84-tAghwS0Hj-XHjPPZ_uYzwHM1sJL7gY0zU6iYMHlsvJKxSF0_t974PA8E2VF6fC4-XsrLLXi1zIXp9CFWB24UGWG9pgCf5cXhWjQUFxiS2xapvAY7IkXoS5DobCUeRQfX4Q6Bq16MS7VaiZPyw7Xtxu9oh0b2O9EjTYMjVHRPW_wJe25C2fAvGt6Eb8tedBSU6cG8tQfux28Cj__bzVtwYwFS2evOq27Dli_vwO7p4hr-Lvw8MVdXk2ntJyUTbNIww2ZVS7wjtAq5KLiTZ1XB6FqAeK6MVCnqLoeiYQtuGHPkcXUohFWUOaOEk8oinm8btMCaWkMJTxPHqH0Eixc29-B8-O7rm-N48ZRD7ARipjijFFfjJaIhnyqRub7JSVimJ21icUfKi57ADmfOFSn3SWJSaTPZd4bgLG5i-vdhu6xK_xBYaoQ1vOcL7y2iEW6dFAXpqOUcHaywETxbzqiedYodutNm5poaq8NgRvAiTPaqiKmnxHFTUl-M3uvkVB0dJRcjPY5gb8Mb1nUSwU8IFcH-0j00hiaNmSl9NW90OshUhhgrgged16xtFSdoirYvw9z_paF6fPb5S_h69C-F92F3_HaoP30YnTyG692BNBHnnsB2W8_9U0RSrd0LAfMLX8EZ7Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Kallikrein+4+is+a+potential+mediator+of+cellular+interactions+between+cancer+cells+and+osteoblasts+in+metastatic+prostate+cancer&rft.jtitle=The+Prostate&rft.au=Gao%2C+Jin&rft.au=Collard%2C+Rachael+L&rft.au=Bui%2C+Loan&rft.au=Herington%2C+Adrian+C&rft.date=2007-03-01&rft.issn=0270-4137&rft.volume=67&rft.issue=4&rft.spage=348&rft.epage=360&rft_id=info:doi/10.1002%2Fpros.20465&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-4137&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-4137&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-4137&client=summon |