Interleukin-21 mediates hepatitis B virus-associated liver cirrhosis by activating hepatic stellate cells

• Published in: Hepatology research Vol. 44; no. 10; pp. E198 - E205
• Main Authors: Feng, Guohua, Zhang, Ji-Yuan, Zeng, Qing-Lei, Yu, Xi, Zhang, Zheng, Lv, Sa, Xu, Xiangsheng, Wang, Fu-Sheng
• Format: Journal Article
• Language: English
• Published: Netherlands Blackwell Publishing Ltd 01.10.2014
• Subjects: hepatic stellate cell; hepatitis B virus-associated liver cirrhosis; interleukin-21; interleukin-21; hepatic stellate cell; hepatitis B virus-associated liver cirrhosis

Aim Interleukin‐21 (IL‐21) is involved in effective primary hepatic immune response against hepatitis B virus (HBV) and profibrotic function. However, the role of IL‐21 in HBV‐associated liver cirrhosis is poorly understood. This study aimed to investigate the role of IL‐21 in HBV‐associated liver c...