Case of bullous pemphigoid refractory to corticosteroids by antiepileptic drug‐induced CYP3A4

• Published in: Journal of dermatology Vol. 50; no. 2; pp. 254 - 257
• Main Authors: Asakawa, Riko, Ogawa, Youichi, Maejima, Eri, Honobe‐Tabuchi, Akiko, Okamoto, Takashi, Mitsui, Hiroshi, Kagawa, Yoshiyuki, Shimada, Shinji, Kawamura, Tatsuyoshi
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2023
• Subjects: Adrenal Cortex Hormones - therapeutic use; Anticonvulsants - therapeutic use; Antiepileptic agents; antiepileptic drugs; Bullous pemphigoid; Case reports; Corticosteroids; CYP3A4; Cytochrome P-450 CYP3A - therapeutic use; Humans; Pemphigoid, Bullous - drug therapy; Phenobarbital; Phenobarbital - therapeutic use; Phenytoin; Phenytoin - therapeutic use; Skin diseases; Steroid hormones; antiepileptic drugs; bullous pemphigoid; corticosteroids; CYP3A4

The most common treatment option for patients with bullous pemphigoid is systemic corticosteroids. CYP3A4, a drug‐metabolizing enzyme in the liver, metabolizes synthetic steroids to a varying degree. Although there are many CYP3A4‐inducing drugs, several antiepileptic drugs, such as phenytoin and ph...