The Role of Nocturnin in Early Adipogenesis and Modulation of Systemic Insulin Resistance in Human

• Published in: Obesity (Silver Spring, Md.) Vol. 20; no. 8; pp. 1558 - 1565
• Main Authors: Hee, Siow‐Wey, Tsai, Shu‐Huei, Chang, Yi‐Cheng, Chang, Ching‐Jin, Yu, I‐Shing, Lee, Po‐Chu, Lee, Wei‐Jei, Chang, Yun‐Chia Emily, Chuang, Lee‐Ming
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2012
• Subjects: 3T3-L1 Cells; Adipogenesis - genetics; Adipogenesis - physiology; Adiponectin - blood; Adiponectin - genetics; Adiponectin - metabolism; Adipose Tissue - metabolism; Adipose Tissue - physiology; Adult; Animals; Body fat; Cell Proliferation; Cellular biology; Cyclin D1 - metabolism; Fasting; Fibroblasts - metabolism; Gene Expression; Genes; Humans; Insulin - blood; Insulin resistance; Insulin Resistance - genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitosis; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Obesity - genetics; Obesity - metabolism; RNA, Messenger - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptome
• ISSN: 1930-7381; 1930-739X; 1930-739X
• DOI: 10.1038/oby.2012.37

The deadenylase nocturnin (Noc, Ccrn4l) has been recently found to regulate lipid metabolism and to control preadipocyte differentiation. Here, we showed that among the five deadenylases tested, Noc and Pan2 exhibited a biphasic expression which is out of phase to each other during adipocyte differe...