Cardiac stress test is normal in pre-motor Parkinson's disease
ABSTRACT Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = ...
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| Published in | Movement disorders Vol. 29; no. 9; pp. 1158 - 1162 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Blackwell Publishing Ltd
01.08.2014
Wiley Subscription Services, Inc |
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| Abstract | ABSTRACT
Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age‐ and sex‐matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow‐up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age‐ and sex‐matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. © 2014 International Parkinson and Movement Disorder Society |
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| AbstractList | Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age‐ and sex‐matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow‐up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years,
P
< 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (
P
< 0.001) and lower heart rate reserve than healthy controls (
P
< 0.001); however, compared with age‐ and sex‐matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. © 2014 International Parkinson and Movement Disorder Society Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD.Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. ABSTRACT Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n = 16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age‐ and sex‐matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow‐up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82 ± 8.82 vs. 48.91 ± 10.60 years, P < 0.001). The time between the first ergometric test and motor symptoms onset was 4.64 ± 2.86 years. Patients who later developed PD had lower maximal heart rate (P < 0.001) and lower heart rate reserve than healthy controls (P < 0.001); however, compared with age‐ and sex‐matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. © 2014 International Parkinson and Movement Disorder Society Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac dysfunction abnormalities in the premotor phase of PD. We retrospectively reviewed treadmill ergometric tests of a large cohort (n=16,841) between 2000 and 2012, that attended the Executive Screening Survey (ESS) at Sheba Medical Center. Heart rate and blood pressure profiles as well as exercise capacity were compared between subjects who later developed PD and age- and sex-matched subjects (ratio 1:2) who did not. We identified 28 subjects (24 males) who developed PD at follow-up. The PD group was older than the group of subjects who did not develop PD on first ergometric test (64.82±8.82 vs. 48.91±10.60 years, P<0.001). The time between the first ergometric test and motor symptoms onset was 4.64±2.86 years. Patients who later developed PD had lower maximal heart rate (P<0.001) and lower heart rate reserve than healthy controls (P<0.001); however, compared with age- and sex-matched subjects, subjects who developed PD had similar exercise capacity and heart rate profile during rest, exercise, and recovery, even 1 year before diagnosis. In this study, we did not detect significant signs of sympathetic dysfunction during the premotor phase of PD. © 2014 International Parkinson and Movement Disorder Society [PUBLICATION ABSTRACT] |
| Author | Sidi, Yechezkel Yahalom, Gilad Maor, Elad Hassin-Baer, Sharon Segev, Shlomo Kivity, Shaye |
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| References | Chahine LM, Stern MB. Diagnostic markers for Parkinson's disease. Curr Opin Neurol 2011;24:309-317. Werner WG, DiFrancisco-Donoghue J, Lamberg EM. Cardiovascular response to treadmill testing in Parkinson disease. J Neurol Phys Ther 2006;30:68-73. Reuter I, Engelhardt M, Freiwaldt J, Baas H. Exercise test in Parkinson's disease. Clin Auton Res 1999;9:129-134. Minguez-Castellanos A, Chamorro CE, Escamilla-Sevilla F, et al. Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study. Neurology 2007;68:2012-2018. Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J 1973;85:546-562. Spiegel J. Diagnostic and pathophysiological impact of myocardial MIBG scintigraphy in Parkinson's disease. Parkinsons Dis 2010;2010: 295346. Goldstein DS, Sharabi Y, Karp BI, et al. Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Cleve Clin J Med 2009;76(Suppl 2):S47-50. Shaye K, Amir T, Shlomo S, Yechezkel S. Fasting glucose levels within the high normal range predict cardiovascular outcome. Am Heart J 2012;164:111-116. Adler CH. Premotor symptoms and early diagnosis of Parkinson's disease. Int J Neurosci 2011;121(Suppl 2):3-8. Bruce RA. Exercise testing of patients with coronary heart disease: principles and normal standards for evaluation. Ann Clin Res 1971;3:323-332. Palma JA, Carmona-Abellan MM, Barriobero N, et al. Is cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study. Mov Disord 2013;28:591-596. DiFrancisco-Donoghue J, Elokda A, Lamberg EM, Bono N, Werner WG. Norepinephrine and cardiovascular responses to maximal exercise in Parkinson's disease on and off medication. Mov Disord 2009;24:1773-1778. Maor E, Kivity S, Kopel E, et al. Differences in heart rate profile during exercise among subjects with subclinical thyroid disease. Thyroid 2013;23:1226-1232. Orimo S, Suzuki M, Inaba A, Mizusawa H. 123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2012;18:494-500. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184. Xu Q, Park Y, Huang X, et al. Physical activities and future risk of Parkinson disease. Neurology 2010;75:341-348. Nakamura T, Hirayama M, Yamashita F, et al. Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease. Mov Disord 2010;25:1183-1189. 2012; 164 2009; 24 2010; 75 2006; 30 2010; 2010 2009; 76 2010; 25 2013; 28 1973; 85 2013; 23 2011; 24 2012; 18 1992; 55 2007; 68 2011; 121 1999; 9 1971; 3 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_13_1 Bruce RA (e_1_2_7_15_1) 1971; 3 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 Spiegel J (e_1_2_7_4_1) 2010; 2010 |
| References_xml | – reference: Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184. – reference: Minguez-Castellanos A, Chamorro CE, Escamilla-Sevilla F, et al. Do alpha-synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study. Neurology 2007;68:2012-2018. – reference: Adler CH. Premotor symptoms and early diagnosis of Parkinson's disease. Int J Neurosci 2011;121(Suppl 2):3-8. – reference: Maor E, Kivity S, Kopel E, et al. Differences in heart rate profile during exercise among subjects with subclinical thyroid disease. Thyroid 2013;23:1226-1232. – reference: Bruce RA. Exercise testing of patients with coronary heart disease: principles and normal standards for evaluation. Ann Clin Res 1971;3:323-332. – reference: Goldstein DS, Sharabi Y, Karp BI, et al. Cardiac sympathetic denervation preceding motor signs in Parkinson disease. Cleve Clin J Med 2009;76(Suppl 2):S47-50. – reference: Reuter I, Engelhardt M, Freiwaldt J, Baas H. Exercise test in Parkinson's disease. Clin Auton Res 1999;9:129-134. – reference: Orimo S, Suzuki M, Inaba A, Mizusawa H. 123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2012;18:494-500. – reference: Werner WG, DiFrancisco-Donoghue J, Lamberg EM. Cardiovascular response to treadmill testing in Parkinson disease. J Neurol Phys Ther 2006;30:68-73. – reference: Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J 1973;85:546-562. – reference: Spiegel J. Diagnostic and pathophysiological impact of myocardial MIBG scintigraphy in Parkinson's disease. Parkinsons Dis 2010;2010: 295346. – reference: Nakamura T, Hirayama M, Yamashita F, et al. Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease. Mov Disord 2010;25:1183-1189. – reference: Xu Q, Park Y, Huang X, et al. Physical activities and future risk of Parkinson disease. Neurology 2010;75:341-348. – reference: Chahine LM, Stern MB. Diagnostic markers for Parkinson's disease. Curr Opin Neurol 2011;24:309-317. – reference: Palma JA, Carmona-Abellan MM, Barriobero N, et al. Is cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study. Mov Disord 2013;28:591-596. – reference: Shaye K, Amir T, Shlomo S, Yechezkel S. Fasting glucose levels within the high normal range predict cardiovascular outcome. Am Heart J 2012;164:111-116. – reference: DiFrancisco-Donoghue J, Elokda A, Lamberg EM, Bono N, Werner WG. Norepinephrine and cardiovascular responses to maximal exercise in Parkinson's disease on and off medication. Mov Disord 2009;24:1773-1778. – volume: 2010 start-page: 295346 year: 2010 article-title: Diagnostic and pathophysiological impact of myocardial MIBG scintigraphy in Parkinson's disease publication-title: Parkinsons Dis – volume: 24 start-page: 1773 year: 2009 end-page: 1778 article-title: Norepinephrine and cardiovascular responses to maximal exercise in Parkinson's disease on and off medication publication-title: Mov Disord – volume: 121 start-page: 3 issue: 2 year: 2011 end-page: 8 article-title: Premotor symptoms and early diagnosis of Parkinson's disease publication-title: Int J Neurosci – volume: 30 start-page: 68 year: 2006 end-page: 73 article-title: Cardiovascular response to treadmill testing in Parkinson disease publication-title: J Neurol Phys Ther – volume: 18 start-page: 494 year: 2012 end-page: 500 article-title: 123I‐MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta‐analysis publication-title: Parkinsonism Relat Disord. – volume: 3 start-page: 323 year: 1971 end-page: 332 article-title: Exercise testing of patients with coronary heart disease: principles and normal standards for evaluation publication-title: Ann Clin Res – volume: 68 start-page: 2012 year: 2007 end-page: 2018 article-title: Do alpha‐synuclein aggregates in autonomic plexuses predate Lewy body disorders?: a cohort study publication-title: Neurology – volume: 25 start-page: 1183 year: 2010 end-page: 1189 article-title: Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease publication-title: Mov Disord – volume: 164 start-page: 111 year: 2012 end-page: 116 article-title: Fasting glucose levels within the high normal range predict cardiovascular outcome publication-title: Am Heart J – volume: 9 start-page: 129 year: 1999 end-page: 134 article-title: Exercise test in Parkinson's disease publication-title: Clin Auton Res – volume: 76 start-page: S47 issue: 2 year: 2009 end-page: 50 article-title: Cardiac sympathetic denervation preceding motor signs in Parkinson disease publication-title: Cleve Clin J Med – volume: 23 start-page: 1226 year: 2013 end-page: 1232 article-title: Differences in heart rate profile during exercise among subjects with subclinical thyroid disease publication-title: Thyroid – volume: 75 start-page: 341 year: 2010 end-page: 348 article-title: Physical activities and future risk of Parkinson disease publication-title: Neurology – volume: 85 start-page: 546 year: 1973 end-page: 562 article-title: Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease publication-title: Am Heart J – volume: 24 start-page: 309 year: 2011 end-page: 317 article-title: Diagnostic markers for Parkinson's disease publication-title: Curr Opin Neurol – volume: 55 start-page: 181 year: 1992 end-page: 184 article-title: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico‐pathological study of 100 cases publication-title: J Neurol Neurosurg Psychiatry – volume: 28 start-page: 591 year: 2013 end-page: 596 article-title: Is cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study publication-title: Mov Disord – ident: e_1_2_7_16_1 doi: 10.1016/0002-8703(73)90502-4 – ident: e_1_2_7_9_1 doi: 10.1007/BF02281625 – ident: e_1_2_7_14_1 doi: 10.1136/jnnp.55.3.181 – ident: e_1_2_7_3_1 doi: 10.1097/WCO.0b013e3283461723 – volume: 2010 start-page: 295346 year: 2010 ident: e_1_2_7_4_1 article-title: Diagnostic and pathophysiological impact of myocardial MIBG scintigraphy in Parkinson's disease publication-title: Parkinsons Dis – ident: e_1_2_7_5_1 doi: 10.1016/j.parkreldis.2012.01.009 – ident: e_1_2_7_11_1 doi: 10.1002/mds.25431 – ident: e_1_2_7_17_1 – ident: e_1_2_7_10_1 doi: 10.1097/01.NPT.0000282570.78544.00 – ident: e_1_2_7_12_1 doi: 10.1016/j.ahj.2012.03.023 – ident: e_1_2_7_2_1 doi: 10.3109/00207454.2011.620192 – ident: e_1_2_7_6_1 doi: 10.3949/ccjm.76.s2.10 – ident: e_1_2_7_19_1 doi: 10.1212/WNL.0b013e3181ea1597 – ident: e_1_2_7_7_1 doi: 10.1212/01.wnl.0000264429.59379.d9 – ident: e_1_2_7_13_1 doi: 10.1089/thy.2013.0043 – ident: e_1_2_7_18_1 doi: 10.1002/mds.22612 – ident: e_1_2_7_8_1 doi: 10.1002/mds.23127 – volume: 3 start-page: 323 year: 1971 ident: e_1_2_7_15_1 article-title: Exercise testing of patients with coronary heart disease: principles and normal standards for evaluation publication-title: Ann Clin Res |
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Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for... Cardiac sympathetic denervation is an early nonmotor feature of Parkinson's disease (PD). The aim of the current study was to trace evidence for cardiac... |
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| SubjectTerms | Aged Blood Pressure - physiology Case-Control Studies Cohort Studies ergometric Ergometry exercise stress test Exercise Test Female Heart Diseases - etiology Heart Rate - physiology Humans Male Middle Aged Movement disorders Parkinson Disease - complications Parkinson's disease preclinical premotor |
| Title | Cardiac stress test is normal in pre-motor Parkinson's disease |
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