Ghrelin promotes renal cell carcinoma metastasis via Snail activation and is associated with poor prognosis - Lin, Tsung-Chieh; Liu, Yu-Peng; Chan, Yung-Chieh; Su, Chia-Yi; Lin, Yuan-Feng; Hsu, Shih-Lan; Yang, Chung-Shi; Hsiao, Michael (The Journal of pathology, 2015)
Keywords: Animals; Binding Sites; Cadherins - genetics; Cadherins - metabolism; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - mortality; Carcinoma, Renal Cell - secondary; Cell Line, Tumor; Cell Movement - drug effects; E-cadherin; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; ghrelin; Ghrelin - genetics; Ghrelin - metabolism; Humans; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Male; metastasis; Mice, Inbred NOD; Mice, SCID; migration; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinase - antagonists & inhibitors; Phosphatidylinositol 3-Kinase - metabolism; Phosphorylation; Promoter Regions, Genetic - drug effects; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Receptors, Ghrelin - genetics; Receptors, Ghrelin - metabolism; renal cell carcinoma; RNA Interference; Signal Transduction; Snail; Snail Family Transcription Factors; Time Factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transfection; migration; ghrelin; renal cell carcinoma; Snail; metastasis; E-cadherin