Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstruction

• Published in: Magnetic resonance in medicine Vol. 62; no. 6; pp. 1543 - 1556
• Main Authors: Holmes, James H., O'Halloran, Rafael L., Brodsky, Ethan K., Bley, Thorsten A., Francois, Christopher J., Velikina, Julia V., Sorkness, Ronald L., Busse, William W., Fain, Sean B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2009
• Subjects: Adult; Algorithms; Asthma; Asthma - diagnosis; Asthma - physiopathology; Contrast Media; Echo-Planar Imaging - methods; Female; Helium; helium-3; Humans; HYPR; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Isotopes; lung; Male; Middle Aged; projection acquisition; Pulmonary Gas Exchange; Reproducibility of Results; Sensitivity and Specificity; ventilation; Young Adult

The purpose of this work is to detect dynamic gas trapping in three dimensions during forced exhalation at isotropic high spatial resolution and high temporal resolution using hyperpolarized helium‐3 MRI. Ten subjects underwent hyperpolarized helium‐3 MRI and multidetector CT. MRI was performed thro...