The burden of community-managed acute respiratory infections in the first 2-years of life

Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high‐risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in...

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Published inPediatric pulmonology Vol. 51; no. 12; pp. 1336 - 1346
Main Authors Sarna, Mohinder, Ware, Robert S., Sloots, Theo P., Nissen, Michael D., Grimwood, Keith, Lambert, Stephen B.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.12.2016
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Abstract Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high‐risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in the first 2‐years of life. Methods One hundred and fifty‐four infants from subtropical Brisbane, Australia participated in a longitudinal, community‐based birth cohort study. A daily tick‐box diary captured pre‐defined respiratory symptoms. Parents also completed a burden diary, recording family physician and hospital visits, and antibiotic use. Results Participants contributed 88,032 child‐days (78.2% of expected), of which 17,316 (19.7%) days were symptomatic during 1,651 ARI episodes: incidence rate 0.56 ARIs per child‐month (95%CI: 0.54, 0.59). Runny nose (14,220 days; 6.0‐days median duration) and dry cough (6,880 days; 4.0‐days median duration) were reported most frequently. Overall, 955 burden diaries recorded 455 family physician visits (1–8 visits per ARI) and 48 hospital presentations, including six hospital admissions. Antibiotics were prescribed on 209 occasions (21.9% of ARI episodes where burden diary submitted). Increasing age, non‐summer seasons, and attendance at childcare were associated with an increased risk of ARI. Conclusions ARIs are a common cause of morbidity in the first 2‐years of life, with children experiencing 13 discrete ARI episodes and almost 5‐months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age‐group. Pediatr Pulmonol. 2016;51:1336–1346. © 2016 Wiley Periodicals, Inc.
AbstractList Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high-risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in the first 2-years of life. One hundred and fifty-four infants from subtropical Brisbane, Australia participated in a longitudinal, community-based birth cohort study. A daily tick-box diary captured pre-defined respiratory symptoms. Parents also completed a burden diary, recording family physician and hospital visits, and antibiotic use. Participants contributed 88,032 child-days (78.2% of expected), of which 17,316 (19.7%) days were symptomatic during 1,651 ARI episodes: incidence rate 0.56 ARIs per child-month (95%CI: 0.54, 0.59). Runny nose (14,220 days; 6.0-days median duration) and dry cough (6,880 days; 4.0-days median duration) were reported most frequently. Overall, 955 burden diaries recorded 455 family physician visits (1-8 visits per ARI) and 48 hospital presentations, including six hospital admissions. Antibiotics were prescribed on 209 occasions (21.9% of ARI episodes where burden diary submitted). Increasing age, non-summer seasons, and attendance at childcare were associated with an increased risk of ARI. ARIs are a common cause of morbidity in the first 2-years of life, with children experiencing 13 discrete ARI episodes and almost 5-months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age-group. Pediatr Pulmonol. 2016;51:1336-1346. © 2016 Wiley Periodicals, Inc.
BACKGROUNDContemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high-risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in the first 2-years of life.METHODSOne hundred and fifty-four infants from subtropical Brisbane, Australia participated in a longitudinal, community-based birth cohort study. A daily tick-box diary captured pre-defined respiratory symptoms. Parents also completed a burden diary, recording family physician and hospital visits, and antibiotic use.RESULTSParticipants contributed 88,032 child-days (78.2% of expected), of which 17,316 (19.7%) days were symptomatic during 1,651 ARI episodes: incidence rate 0.56 ARIs per child-month (95%CI: 0.54, 0.59). Runny nose (14,220 days; 6.0-days median duration) and dry cough (6,880 days; 4.0-days median duration) were reported most frequently. Overall, 955 burden diaries recorded 455 family physician visits (1-8 visits per ARI) and 48 hospital presentations, including six hospital admissions. Antibiotics were prescribed on 209 occasions (21.9% of ARI episodes where burden diary submitted). Increasing age, non-summer seasons, and attendance at childcare were associated with an increased risk of ARI.CONCLUSIONSARIs are a common cause of morbidity in the first 2-years of life, with children experiencing 13 discrete ARI episodes and almost 5-months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age-group. Pediatr Pulmonol. 2016;51:1336-1346. © 2016 Wiley Periodicals, Inc.
Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high‐risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in the first 2‐years of life. Methods One hundred and fifty‐four infants from subtropical Brisbane, Australia participated in a longitudinal, community‐based birth cohort study. A daily tick‐box diary captured pre‐defined respiratory symptoms. Parents also completed a burden diary, recording family physician and hospital visits, and antibiotic use. Results Participants contributed 88,032 child‐days (78.2% of expected), of which 17,316 (19.7%) days were symptomatic during 1,651 ARI episodes: incidence rate 0.56 ARIs per child‐month (95%CI: 0.54, 0.59). Runny nose (14,220 days; 6.0‐days median duration) and dry cough (6,880 days; 4.0‐days median duration) were reported most frequently. Overall, 955 burden diaries recorded 455 family physician visits (1–8 visits per ARI) and 48 hospital presentations, including six hospital admissions. Antibiotics were prescribed on 209 occasions (21.9% of ARI episodes where burden diary submitted). Increasing age, non‐summer seasons, and attendance at childcare were associated with an increased risk of ARI. Conclusions ARIs are a common cause of morbidity in the first 2‐years of life, with children experiencing 13 discrete ARI episodes and almost 5‐months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age‐group. Pediatr Pulmonol. 2016;51:1336–1346. © 2016 Wiley Periodicals, Inc.
Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high-risk birth cohort studies. We describe the burden and determinants of symptomatic episodes of ARIs in unselected healthy infants in the first 2-years of life. Methods One hundred and fifty-four infants from subtropical Brisbane, Australia participated in a longitudinal, community-based birth cohort study. A daily tick-box diary captured pre-defined respiratory symptoms. Parents also completed a burden diary, recording family physician and hospital visits, and antibiotic use. Results Participants contributed 88,032 child-days (78.2% of expected), of which 17,316 (19.7%) days were symptomatic during 1,651 ARI episodes: incidence rate 0.56 ARIs per child-month (95%CI: 0.54, 0.59). Runny nose (14,220 days; 6.0-days median duration) and dry cough (6,880 days; 4.0-days median duration) were reported most frequently. Overall, 955 burden diaries recorded 455 family physician visits (1-8 visits per ARI) and 48 hospital presentations, including six hospital admissions. Antibiotics were prescribed on 209 occasions (21.9% of ARI episodes where burden diary submitted). Increasing age, non-summer seasons, and attendance at childcare were associated with an increased risk of ARI. Conclusions ARIs are a common cause of morbidity in the first 2-years of life, with children experiencing 13 discrete ARI episodes and almost 5-months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age-group. Pediatr Pulmonol. 2016;51:1336-1346. © 2016 Wiley Periodicals, Inc.
Author Sarna, Mohinder
Ware, Robert S.
Sloots, Theo P.
Lambert, Stephen B.
Nissen, Michael D.
Grimwood, Keith
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  email: m.sarna@uq.edu.au, Correspondence to: Mohinder Sarna, MAppEpi, Centre for Children's Health Research (LCCH), 62 Graham Street, South Brisbane, Queensland 4101, Australia. , m.sarna@uq.edu.au
  organization: School of Public Health, The University of Queensland, Brisbane, Queensland, Australia
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  givenname: Stephen B.
  surname: Lambert
  fullname: Lambert, Stephen B.
  organization: Queensland Pediatric Infectious Diseases Laboratory, Centre for Children's Health Research, Children's Health Queensland, Brisbane, Queensland, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27228308$$D View this record in MEDLINE/PubMed
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respiratory symptoms
children
management
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2015; 202
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2013; 347
2015; 100
2008; 38
2002; 112
2002; 8
2007; 120
2010; 341
2008
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2013; 7
1953; 58
2012; 12
2013; 381
2006; 117
2006; 355
2009; 28
2012; 2
2007; 119
2003; 327
1971; 94
2010; 29
1992; 157
2006; 25
1986; 140
2015; 65
2008; 46
2005; 6
2008; 43
2009; 360
2000; 342
2013; 132
2007; 43
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Chonmaitree (10.1002/ppul.23480-BIB0003|ppul23480-cit-0003) 2008; 46
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Snippet Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations,...
Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and high-risk birth...
Summary Background Contemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations,...
BACKGROUNDContemporary information on acute respiratory infections (ARIs) in children is based on hospital cohorts, primary healthcare presentations, and...
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SubjectTerms Acute Disease
Ambulatory Care
Australia - epidemiology
Child, Preschool
children
Cohort Studies
Cough - epidemiology
Cough - therapy
Dyspnea - epidemiology
Dyspnea - therapy
Female
Humans
Incidence
Infant
Longitudinal Studies
Male
management
Morbidity
Otitis Media - epidemiology
Otitis Media - therapy
Pneumonia - epidemiology
Pneumonia - therapy
Primary Health Care
Respiratory Sounds
respiratory symptoms
respiratory tract infections
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - therapy
Title The burden of community-managed acute respiratory infections in the first 2-years of life
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fppul.23480
https://www.ncbi.nlm.nih.gov/pubmed/27228308
https://www.proquest.com/docview/1845453947
https://search.proquest.com/docview/1826686978
Volume 51
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