Association of dopamine D2/3 receptor binding potential measured using PET and [11C]-(+)-PHNO with post-mortem DRD2/3 gene expression in the human brain

• Published in: NeuroImage (Orlando, Fla.) Vol. 223; p. 117270
• Main Authors: Komorowski, Arkadiusz, Weidenauer, Ana, Murgaš, Matej, Sauerzopf, Ulrich, Wadsak, Wolfgang, Mitterhauser, Markus, Bauer, Martin, Hacker, Marcus, Praschak-Rieder, Nicole, Kasper, Siegfried, Lanzenberger, Rupert, Willeit, Matthäus
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2020; Elsevier
• Subjects: [11C]-(+)-PHNO; D2/3; Dopamine; mRNA; mRNA; Dopamine; [11C]-(+)-PHNO; D2/3

Open access post-mortem transcriptome atlases such as the Allen Human Brain Atlas (AHBA) can inform us about mRNA expression of numerous proteins of interest across the whole brain, while in vivo protein binding in the human brain can be quantified by means of neuroreceptor positron emission tomogra...