Epidemiology of Nontuberculous Mycobacterial Infections and Associated Chronic Macrolide Use among Persons with Cystic Fibrosis

• Published in: American journal of respiratory and critical care medicine Vol. 188; no. 7; pp. 807 - 812
• Main Authors: Binder, Alison M., Adjemian, Jennifer, Olivier, Kenneth N., Prevots, D. Rebecca
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 01.10.2013
• Subjects: Adolescent; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - therapeutic use; Azithromycin - administration & dosage; Azithromycin - adverse effects; Azithromycin - therapeutic use; Bacterial diseases; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Comorbidity; Cystic fibrosis; Cystic Fibrosis - drug therapy; Cystic Fibrosis - epidemiology; Cystic Fibrosis - microbiology; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Errors of metabolism; Female; Human bacterial diseases; Humans; Infections; Infectious diseases; Intensive care medicine; Macrolides - administration & dosage; Macrolides - adverse effects; Macrolides - therapeutic use; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Mutation; Mycobacterium Infections, Nontuberculous - epidemiology; Mycobacterium Infections, Nontuberculous - microbiology; Nontuberculous Mycobacteria - isolation & purification; Patients; Pediatrics; Pneumology; Registries; Regression analysis; Tuberculosis and atypical mycobacterial infections; Young Adult; United States > US; Intensive care; Respiratory disease; Use; Metabolic diseases; Cystic fibrosis; nontuberculous mycobacteria; Mycobacterial infection; Epidemiology; Macrolide; Differential diagnostic; Genetic disease; Infection; Chronic; macrolides; Bacteriosis; Digestive diseases; Antibacterial agent; Resuscitation; Public health; Pancreatic disease

Persons with cystic fibrosis (CF) are at high risk of nontuberculous mycobacterial (NTM) infection, with treatment requiring prolonged multidrug regimens that include macrolides. Although macrolides, specifically azithromycin, are used in the management of patients with CF with chronic Pseudomonas,...