Estrogen-Mediated Regulation of Mitochondrial Gene Expression

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 29; no. 1; pp. 14 - 27
• Main Authors: Lopez Sanchez, Maria I. G, Shearwood, Anne-Marie J, Chia, Tiongsun, Davies, Stefan M. K, Rackham, Oliver, Filipovska, Aleksandra
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.01.2015; Oxford University Press
• Subjects: 3-Hydroxyacyl CoA Dehydrogenases - biosynthesis; 3-Hydroxyacyl CoA Dehydrogenases - genetics; 3-Hydroxyacyl CoA Dehydrogenases - metabolism; Cell Line, Tumor; Estradiol - metabolism; Estrogen Receptor alpha - biosynthesis; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Estrogens - metabolism; Gene Expression Regulation - genetics; Genes, Mitochondrial - genetics; Humans; MCF-7 Cells; Mitochondria - enzymology; Mitochondria - genetics; Mitochondria - metabolism; Original Research; RNA Interference; RNA, Small Interfering

Estrogens, in particular 17β-estradiol, are well-known regulators of essential cellular functions; however, discrepancies remain over the mechanisms by which they act on mitochondria. Here we propose a novel mechanism for the direct regulation of mitochondrial gene expression by estrogen under metab...