Test Variability of the QuantiFERON-TB Gold In-Tube Assay in Clinical Practice

• Published in: American journal of respiratory and critical care medicine Vol. 187; no. 2; pp. 206 - 211
• Main Authors: Metcalfe, John Z., Cattamanchi, Adithya, McCulloch, Charles E., Lew, Justin D., Ha, Ngan P., Graviss, Edward A.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.01.2013
• Subjects: Adult; Agreements; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Control algorithms; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; Female; Humans; Immunoassay - methods; Immunoassay - standards; Industrialized nations; Infections; Intensive care medicine; Interferon-gamma - immunology; Laboratories; Latent Tuberculosis - diagnosis; Male; Medical sciences; Population; Quality control; Reagent Kits, Diagnostic; Reproducibility of Results; Tuberculosis; Australia; repeatability; imprecision; Intensive care; interferon-γ release assay; Variability; Cytokine; Interferon; QuantiFERON; Resuscitation

Although IFN-γ release assays (IGRAs) are widely used to screen for Mycobacterium tuberculosis infection in high-income countries, published data on repeatability are limited. To determine IGRA repeatability. The study population included consecutive patients referred to The Methodist Hospital (Hous...