Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling

• Published in: Stem cell research & therapy Vol. 8; no. 1; p. 34
• Main Authors: Cheng, Gesheng, Wang, Xingye, Li, Yongxin, He, Lu
• Format: Journal Article
• Language: English
• Published: England BioMed Central 10.02.2017
• Subjects: Adenoviridae; Adenoviridae - genetics; Adenoviridae - metabolism; Animals; Bone Morphogenetic Protein Receptors, Type II - genetics; Bone Morphogenetic Protein Receptors, Type II - metabolism; Coculture Techniques; Gene Expression Regulation; Genetic Vectors - chemistry; Genetic Vectors - metabolism; Humans; Hypertension, Pulmonary - chemically induced; Hypertension, Pulmonary - pathology; Hypertension, Pulmonary - physiopathology; Hypertension, Pulmonary - therapy; Hypertrophy, Right Ventricular - chemically induced; Hypertrophy, Right Ventricular - pathology; Hypertrophy, Right Ventricular - physiopathology; Hypertrophy, Right Ventricular - therapy; Lung - blood supply; Lung - pathology; Lung - physiopathology; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; Monocrotaline; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Rats; Rats, Inbred Lew; Signal Transduction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transfection; STAT3 pathway; Pulmonary arterial hypertension; BMPR2; let-7a; pulmonary artery smooth muscle cell; mesenchymal stem cells
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-017-0480-y

Cell-based gene therapy has become a subject of interest for the treatment of pulmonary arterial hypertension (PAH), a devastating disease characterized by pulmonary artery smooth muscle cell (PASMC) hyperplasia. Mesenchymal stem cells (MSCs) have been recently acknowledged as a potential cell vecto...