Incidental (unreinforced) and reinforced spatial learning in rats with ventral and dorsal lesions of the hippocampus
We investigated whether the ventral and dorsal hippocampus were differentially involved in incidental spatial learning. Rats with ventral and dorsal hippocampal lesions were tested on an unreinforced test of spatial memory that takes advantage of their natural propensity to explore novelty. Rats wer...
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Published in | Behavioural brain research Vol. 202; no. 1; pp. 64 - 70 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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24.08.2009
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Abstract | We investigated whether the ventral and dorsal hippocampus were differentially involved in incidental spatial learning. Rats with ventral and dorsal hippocampal lesions were tested on an unreinforced test of spatial memory that takes advantage of their natural propensity to explore novelty. Rats were presented with two copies of an identical object in a large circular open field arena. Subsequently, the rats were placed back into the open field with one of the objects displaced to an adjacent quadrant of the arena. Sham-operated rats and rats with ventral hippocampal lesions spent more time in the quadrant that contained the displaced object than in the quadrant that contained the non-displaced object, and more time investigating the displaced object than the non-displaced object. Rats with dorsal hippocampal lesions were impaired on both measures. Both sham and ventral hippocampal lesioned rats subsequently learned to retrieve a food pellet in the ends of each arm of a radial maze. Rats with lesions to the dorsal hippocampus showed no significant improvement in the number of errors made across training sessions and made significantly more errors, overall, than rats with ventral hippocampal or sham lesions. The findings suggest that an intact dorsal but not ventral hippocampus is necessary for spatial learning in rats. |
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AbstractList | We investigated whether the ventral and dorsal hippocampus were differentially involved in incidental spatial learning. Rats with ventral and dorsal hippocampal lesions were tested on an unreinforced test of spatial memory that takes advantage of their natural propensity to explore novelty. Rats were presented with two copies of an identical object in a large circular open field arena. Subsequently, the rats were placed back into the open field with one of the objects displaced to an adjacent quadrant of the arena. Sham-operated rats and rats with ventral hippocampal lesions spent more time in the quadrant that contained the displaced object than in the quadrant that contained the non-displaced object, and more time investigating the displaced object than the non-displaced object. Rats with dorsal hippocampal lesions were impaired on both measures. Both sham and ventral hippocampal lesioned rats subsequently learned to retrieve a food pellet in the ends of each arm of a radial maze. Rats with lesions to the dorsal hippocampus showed no significant improvement in the number of errors made across training sessions and made significantly more errors, overall, than rats with ventral hippocampal or sham lesions. The findings suggest that an intact dorsal but not ventral hippocampus is necessary for spatial learning in rats. |
Author | Cole, Emily Tardif, Marilyn Mumby, Dave G. Gaskin, Stephane Gamliel, Anafa |
Author_xml | – sequence: 1 givenname: Stephane surname: Gaskin fullname: Gaskin, Stephane email: sgaskin@alcor.concordia.ca – sequence: 2 givenname: Anafa surname: Gamliel fullname: Gamliel, Anafa – sequence: 3 givenname: Marilyn surname: Tardif fullname: Tardif, Marilyn – sequence: 4 givenname: Emily surname: Cole fullname: Cole, Emily – sequence: 5 givenname: Dave G. surname: Mumby fullname: Mumby, Dave G. |
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Keywords | NMDA Exploration Radial maze Latent learning Novelty preference Spatial memory Rat Rodentia Central nervous system Space perception Novelty stimulus Encephalon Vertebrata Mammalia Acquisition process Animal Latentlearning Lesion Stimulus preference Perceptive learning Hippocampus |
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Snippet | We investigated whether the ventral and dorsal hippocampus were differentially involved in incidental spatial learning. Rats with ventral and dorsal... |
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SubjectTerms | Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Exploration Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiology Latent learning Learning - physiology Male Maze Learning - physiology Memory - physiology N-Methylaspartate - toxicity Neurotoxins - toxicity NMDA Novelty preference Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radial maze Rats Rats, Long-Evans Space Perception - physiology Spatial Behavior - physiology Spatial memory Time Factors |
Title | Incidental (unreinforced) and reinforced spatial learning in rats with ventral and dorsal lesions of the hippocampus |
URI | https://dx.doi.org/10.1016/j.bbr.2009.03.016 https://www.ncbi.nlm.nih.gov/pubmed/19447282 https://search.proquest.com/docview/20603492 |
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