IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

• Published in: American journal of respiratory and critical care medicine Vol. 188; no. 4; pp. 432 - 439
• Main Authors: Shaw, Joanne L., Fakhri, Samer, Citardi, Martin J., Porter, Paul C., Corry, David B., Kheradmand, Farrah, Liu, Yong-Jun, Luong, Amber
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.08.2013
• Subjects: Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Cell culture; Chronic Disease; Cytokines; Epithelial Cells - metabolism; Female; Flow Cytometry; Humans; Immunity, Innate - physiology; Inflammatory diseases; Intensive care medicine; Interleukin-33; Interleukins - metabolism; Interleukins - physiology; Male; Medical sciences; Middle Aged; Mucous Membrane - metabolism; Nasal Polyps - metabolism; Non tumoral diseases; Otorhinolaryngology. Stomatology; Pathophysiology; Patients; Pneumology; Polyps; Rhinitis - complications; Rhinitis - immunology; Rhinitis - metabolism; Rhinitis - physiopathology; Sinuses; Sinusitis - complications; Sinusitis - immunology; Sinusitis - metabolism; Sinusitis - physiopathology; Software; Th2 Cells - immunology; Th2 Cells - metabolism; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Nose disease; Lymphoid cell; Intensive care; Nasal polyp; Rhinitis; Upper respiratory tract; Respiratory disease; Cytokine; epithelial cells; Interleukin 13; Alternaria alternata; innate lymphoid cells; IL-33; Sinusitis; Source; Fungi; Chronic; ENT disease; Epithelial cell; Paranasal sinus disease; Fungi Imperfecti; Aspergillus fumigatus; Resuscitation

Chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) are associated with Th1 and Th2 cytokine polarization, respectively; however, the pathophysiology of CRS remains unclear. The importance of innate lymphoid cells in Th2-mediated inflammatory disease has not...