Mechanisms Involved in 3′,5′-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle

Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of β2-adrenoceptors (AR) and cAMP in regulating the ubiquitin-proteasome system (UPS) in skeletal muscle. W...

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Published inEndocrinology (Philadelphia) Vol. 150; no. 12; pp. 5395 - 5404
Main Authors Gonçalves, Dawit A. P, Lira, Eduardo C, Baviera, Amanda M, Cao, Peirang, Zanon, Neusa M, Arany, Zoltan, Bedard, Nathalie, Tanksale, Preeti, Wing, Simon S, Lecker, Stewart H, Kettelhut, Isis C, Navegantes, Luiz C. C
Format Journal Article
LanguageEnglish
Published United States Endocrine Society 01.12.2009
Oxford University Press
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Abstract Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of β2-adrenoceptors (AR) and cAMP in regulating the ubiquitin-proteasome system (UPS) in skeletal muscle. We report that increased levels of cAMP in isolated muscles, promoted by the cAMP phosphodiesterase inhibitor isobutylmethylxanthine was accompanied by decreased activity of the UPS, levels of ubiquitin-protein conjugates, and expression of atrogin-1, a key ubiquitin-protein ligase involved in muscle atrophy. In cultured myotubes, atrogin-1 induction after dexamethasone treatment was completely prevented by isobutylmethylxanthine. Furthermore, administration of clenbuterol, a selective β2-agonist, to mice increased muscle cAMP levels and suppressed the fasting-induced expression of atrogin-1 and MuRF-1, atrogin-1 mRNA being much more responsive to clenbuterol. Moreover, clenbuterol increased the phosphorylation of muscle Akt and Foxo3a in fasted rats. Similar responses were observed in muscles exposed to dibutyryl-cAMP. The stimulatory effect of clenbuterol on cAMP and Akt was abolished in muscles from β2-AR knockout mice. The suppressive effect of β2-agonist on atrogin-1 was not mediated by PGC-1α (peroxisome proliferator-activated receptor-γ coactivator 1α known to be induced by β2-agonists and previously shown to inhibit atrogin-1 expression), because food-deprived PGC-1α knockout mice were still sensitive to clenbuterol. These findings suggest that the cAMP increase induced by stimulation of β2-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. The cAMP increase induced by stimulation of β2-adrenoceptors is possibly the mechanism by which clenbuterol, via Akt/Foxo3 signaling, attenuate the fasting-induced muscle atrophy.
AbstractList Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of beta(2)-adrenoceptors (AR) and cAMP in regulating the ubiquitin-proteasome system (UPS) in skeletal muscle. We report that increased levels of cAMP in isolated muscles, promoted by the cAMP phosphodiesterase inhibitor isobutylmethylxanthine was accompanied by decreased activity of the UPS, levels of ubiquitin-protein conjugates, and expression of atrogin-1, a key ubiquitin-protein ligase involved in muscle atrophy. In cultured myotubes, atrogin-1 induction after dexamethasone treatment was completely prevented by isobutylmethylxanthine. Furthermore, administration of clenbuterol, a selective beta(2)-agonist, to mice increased muscle cAMP levels and suppressed the fasting-induced expression of atrogin-1 and MuRF-1, atrogin-1 mRNA being much more responsive to clenbuterol. Moreover, clenbuterol increased the phosphorylation of muscle Akt and Foxo3a in fasted rats. Similar responses were observed in muscles exposed to dibutyryl-cAMP. The stimulatory effect of clenbuterol on cAMP and Akt was abolished in muscles from beta(2)-AR knockout mice. The suppressive effect of beta(2)-agonist on atrogin-1 was not mediated by PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator 1alpha known to be induced by beta(2)-agonists and previously shown to inhibit atrogin-1 expression), because food-deprived PGC-1alpha knockout mice were still sensitive to clenbuterol. These findings suggest that the cAMP increase induced by stimulation of beta(2)-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3.
Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of β2-adrenoceptors (AR) and cAMP in regulating the ubiquitin-proteasome system (UPS) in skeletal muscle. We report that increased levels of cAMP in isolated muscles, promoted by the cAMP phosphodiesterase inhibitor isobutylmethylxanthine was accompanied by decreased activity of the UPS, levels of ubiquitin-protein conjugates, and expression of atrogin-1, a key ubiquitin-protein ligase involved in muscle atrophy. In cultured myotubes, atrogin-1 induction after dexamethasone treatment was completely prevented by isobutylmethylxanthine. Furthermore, administration of clenbuterol, a selective β2-agonist, to mice increased muscle cAMP levels and suppressed the fasting-induced expression of atrogin-1 and MuRF-1, atrogin-1 mRNA being much more responsive to clenbuterol. Moreover, clenbuterol increased the phosphorylation of muscle Akt and Foxo3a in fasted rats. Similar responses were observed in muscles exposed to dibutyryl-cAMP. The stimulatory effect of clenbuterol on cAMP and Akt was abolished in muscles from β2-AR knockout mice. The suppressive effect of β2-agonist on atrogin-1 was not mediated by PGC-1α (peroxisome proliferator-activated receptor-γ coactivator 1α known to be induced by β2-agonists and previously shown to inhibit atrogin-1 expression), because food-deprived PGC-1α knockout mice were still sensitive to clenbuterol. These findings suggest that the cAMP increase induced by stimulation of β2-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3.
Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was undertaken to investigate the role of β2-adrenoceptors (AR) and cAMP in regulating the ubiquitin-proteasome system (UPS) in skeletal muscle. We report that increased levels of cAMP in isolated muscles, promoted by the cAMP phosphodiesterase inhibitor isobutylmethylxanthine was accompanied by decreased activity of the UPS, levels of ubiquitin-protein conjugates, and expression of atrogin-1, a key ubiquitin-protein ligase involved in muscle atrophy. In cultured myotubes, atrogin-1 induction after dexamethasone treatment was completely prevented by isobutylmethylxanthine. Furthermore, administration of clenbuterol, a selective β2-agonist, to mice increased muscle cAMP levels and suppressed the fasting-induced expression of atrogin-1 and MuRF-1, atrogin-1 mRNA being much more responsive to clenbuterol. Moreover, clenbuterol increased the phosphorylation of muscle Akt and Foxo3a in fasted rats. Similar responses were observed in muscles exposed to dibutyryl-cAMP. The stimulatory effect of clenbuterol on cAMP and Akt was abolished in muscles from β2-AR knockout mice. The suppressive effect of β2-agonist on atrogin-1 was not mediated by PGC-1α (peroxisome proliferator-activated receptor-γ coactivator 1α known to be induced by β2-agonists and previously shown to inhibit atrogin-1 expression), because food-deprived PGC-1α knockout mice were still sensitive to clenbuterol. These findings suggest that the cAMP increase induced by stimulation of β2-AR in skeletal muscles from fasted mice is possibly the mechanism by which catecholamines suppress atrogin-1 and the UPS, this effect being mediated via phosphorylation of Akt and thus inactivation of Foxo3. The cAMP increase induced by stimulation of β2-adrenoceptors is possibly the mechanism by which clenbuterol, via Akt/Foxo3 signaling, attenuate the fasting-induced muscle atrophy.
Author Bedard, Nathalie
Gonçalves, Dawit A. P
Arany, Zoltan
Zanon, Neusa M
Cao, Peirang
Lira, Eduardo C
Tanksale, Preeti
Baviera, Amanda M
Lecker, Stewart H
Kettelhut, Isis C
Wing, Simon S
Navegantes, Luiz C. C
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  surname: Kettelhut
  fullname: Kettelhut, Isis C
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  givenname: Luiz C. C
  surname: Navegantes
  fullname: Navegantes, Luiz C. C
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19837877$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1097/SHK.0b013e31802e43a6
10.1113/jphysiol.2002.034850
10.1016/S0092-8674(00)80611-X
10.1210/jc.2003-031733
10.1152/physrev.00028.2007
10.1016/j.biocel.2005.02.026
10.1074/jbc.M110856200
10.1681/ASN.2006010083
10.1152/japplphysiol.91067.2008
10.1016/S0021-9258(19)52451-6
10.1097/00075197-200205000-00007
10.1139/y02-149
10.1152/japplphysiol.90880.2008
10.1152/ajpendo.00147.2006
10.1152/ajpregu.00617.2006
10.1016/j.cellsig.2005.03.011
10.1152/japplphysiol.00448.2004
10.1152/ajpendo.00073.2004
10.1210/en.2006-1646
10.1172/JCI117929
10.1073/pnas.251541198
10.1016/S0092-8674(04)00400-3
10.1152/japplphysiol.00873.2006
10.1152/ajpendo.2000.279.3.E663
10.1073/pnas.0607795103
10.1002/mus.20416
10.1126/science.1065874
10.1182/blood-2002-03-0788
10.1152/ajpendo.00371.2003
10.1002/jcb.20371
10.1677/joe.0.1630015
10.1152/japplphysiol.00089.2007
10.1152/ajpendo.2001.281.3.E449
10.1042/bj20030200
10.1023/A:1006955832323
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References Gomes (2020071612423829400_R12) 2001; 98
Vary (2020071612423829400_R27) 1999; 163
Hinkle (2020071612423829400_R6) 2005; 32
Sacheck (2020071612423829400_R30) 2004; 287
Navegantes (2020071612423829400_R2) 2002; 5
Bacurau (2020071612423829400_R34) 2009; 106
Miura (2020071612423829400_R16) 2007; 146
Navegantes (2020071612423829400_R20) 2001; 281
Wu (2020071612423829400_R18) 1999; 98
Bloom (2020071612423829400_R26) 2002; 80
Viguerie (2020071612423829400_R1) 2004; 89
Nader (2020071612423829400_R35) 2005; 37
Frost (2020071612423829400_R36) 2007; 103
Lynch (2020071612423829400_R3) 2008; 88
Pilegaard (2020071612423829400_R15) 2003; 546
Gibala (2020071612423829400_R17) 2009; 106
Combaret (2020071612423829400_R7) 1999; 26
Lecker (2020071612423829400_R10) 2006; 17
Yimlamai (2020071612423829400_R28) 2005; 99
Sandri (2020071612423829400_R13) 2004; 117
Navegantes (2020071612423829400_R4) 2000; 279
Navegantes (2020071612423829400_R5) 2004; 286
Baviera (2020071612423829400_R9) 2007; 292
De Rooji (2020071612423829400_R31) 2000; 275
Okuno (2020071612423829400_R22) 2002; 100
Brennesvik (2020071612423829400_R33) 2005; 17
Mei (2020071612423829400_R32) 2002; 29
Bdolah (2020071612423829400_R25) 2007; 292
Waalkes (2020071612423829400_R21) 1957; 50
Bodine (2020071612423829400_R11) 2001; 294
Kline (2020071612423829400_R14) 2007; 102
Costelli (2020071612423829400_R29) 1995; 95
Meirhaeghe (2020071612423829400_R37) 2003; 373
Yang (2020071612423829400_R23) 2005; 94
Sandri (2020071612423829400_R19) 2006; 103
Lowry (2020071612423829400_R24) 1951; 193
Lira (2020071612423829400_R8) 2007; 27
References_xml – volume: 27
  start-page: 687
  year: 2007
  ident: 2020071612423829400_R8
  article-title: Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats.
  publication-title: Shock
  doi: 10.1097/SHK.0b013e31802e43a6
  contributor:
    fullname: Lira
– volume: 546
  start-page: 851
  year: 2003
  ident: 2020071612423829400_R15
  article-title: Exercise induces transient transcriptional activation of the PGC-1α gene in skeletal muscle.
  publication-title: J Physiol
  doi: 10.1113/jphysiol.2002.034850
  contributor:
    fullname: Pilegaard
– volume: 98
  start-page: 115
  year: 1999
  ident: 2020071612423829400_R18
  article-title: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80611-X
  contributor:
    fullname: Wu
– volume: 89
  start-page: 2000
  year: 2004
  ident: 2020071612423829400_R1
  article-title: In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle.
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2003-031733
  contributor:
    fullname: Viguerie
– volume: 88
  start-page: 729
  year: 2008
  ident: 2020071612423829400_R3
  article-title: Role of β-adrenoceptor signaling in skeletal muscle: implication for muscle wasting and disease.
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00028.2007
  contributor:
    fullname: Lynch
– volume: 37
  start-page: 1985
  year: 2005
  ident: 2020071612423829400_R35
  article-title: Molecular determinants of skeletal muscle mass: getting the “AKT” together.
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2005.02.026
  contributor:
    fullname: Nader
– volume: 29
  start-page: 11497
  year: 2002
  ident: 2020071612423829400_R32
  article-title: Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110856200
  contributor:
    fullname: Mei
– volume: 17
  start-page: 1807
  year: 2006
  ident: 2020071612423829400_R10
  article-title: Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2006010083
  contributor:
    fullname: Lecker
– volume: 106
  start-page: 1631
  year: 2009
  ident: 2020071612423829400_R34
  article-title: Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training.
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.91067.2008
  contributor:
    fullname: Bacurau
– volume: 193
  start-page: 265
  year: 1951
  ident: 2020071612423829400_R24
  article-title: Protein measurement with the Folin phenol reagent.
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)52451-6
  contributor:
    fullname: Lowry
– volume: 5
  start-page: 281
  year: 2002
  ident: 2020071612423829400_R2
  article-title: Adrenergic control of protein metabolism in skeletal muscle.
  publication-title: Curr Opin Clin Nutr Metab Care
  doi: 10.1097/00075197-200205000-00007
  contributor:
    fullname: Navegantes
– volume: 50
  start-page: 733
  year: 1957
  ident: 2020071612423829400_R21
  article-title: A fluorometric method for the estimation of tyrosine in plasma and tissues.
  publication-title: J Lab Clin Invest
  contributor:
    fullname: Waalkes
– volume: 80
  start-page: 1132
  year: 2002
  ident: 2020071612423829400_R26
  article-title: Cyclic nucleotide phosphodiesterase isozymes expressed in mouse skeletal muscle.
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/y02-149
  contributor:
    fullname: Bloom
– volume: 106
  start-page: 929
  year: 2009
  ident: 2020071612423829400_R17
  article-title: Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle.
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.90880.2008
  contributor:
    fullname: Gibala
– volume: 292
  start-page: E702
  year: 2007
  ident: 2020071612423829400_R9
  article-title: Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00147.2006
  contributor:
    fullname: Baviera
– volume: 292
  start-page: R971
  year: 2007
  ident: 2020071612423829400_R25
  article-title: Atrophy-related ubiquitin ligases atrogin-1 and MuRF-1 are associated with uterine smooth muscle involution in the postpartum period
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00617.2006
  contributor:
    fullname: Bdolah
– volume: 275
  start-page: 20829
  year: 2000
  ident: 2020071612423829400_R31
  article-title: Mechanisms of regulation of the Epac family of cAMP-dependent Rap GEFs.
  publication-title: J Biol Biochem
  contributor:
    fullname: De Rooji
– volume: 17
  start-page: 1551
  year: 2005
  ident: 2020071612423829400_R33
  article-title: Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for crosstalk between insulin and adrenaline.
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2005.03.011
  contributor:
    fullname: Brennesvik
– volume: 99
  start-page: 71
  year: 2005
  ident: 2020071612423829400_R28
  article-title: Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway.
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.00448.2004
  contributor:
    fullname: Yimlamai
– volume: 287
  start-page: E591
  year: 2004
  ident: 2020071612423829400_R30
  article-title: IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00073.2004
  contributor:
    fullname: Sacheck
– volume: 146
  start-page: 3441
  year: 2007
  ident: 2020071612423829400_R16
  article-title: An increase in murine skeletal muscle peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to exercise is mediated by β-adrenergic receptor activation.
  publication-title: Endocrinology
  doi: 10.1210/en.2006-1646
  contributor:
    fullname: Miura
– volume: 95
  start-page: 2367
  year: 1995
  ident: 2020071612423829400_R29
  article-title: Muscle protein waste in tumor-bearing rats is effectively antagonized by a β2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway.
  publication-title: J Clin Invest
  doi: 10.1172/JCI117929
  contributor:
    fullname: Costelli
– volume: 98
  start-page: 14440
  year: 2001
  ident: 2020071612423829400_R12
  article-title: Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.251541198
  contributor:
    fullname: Gomes
– volume: 117
  start-page: 399
  year: 2004
  ident: 2020071612423829400_R13
  article-title: Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
  publication-title: Cell
  doi: 10.1016/S0092-8674(04)00400-3
  contributor:
    fullname: Sandri
– volume: 102
  start-page: 740
  year: 2007
  ident: 2020071612423829400_R14
  article-title: Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol.
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.00873.2006
  contributor:
    fullname: Kline
– volume: 279
  start-page: E663
  year: 2000
  ident: 2020071612423829400_R4
  article-title: Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.2000.279.3.E663
  contributor:
    fullname: Navegantes
– volume: 103
  start-page: 16260
  year: 2006
  ident: 2020071612423829400_R19
  article-title: PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy specific gene transcription.
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0607795103
  contributor:
    fullname: Sandri
– volume: 32
  start-page: 775
  year: 2005
  ident: 2020071612423829400_R6
  article-title: Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy.
  publication-title: Muscle Nerve
  doi: 10.1002/mus.20416
  contributor:
    fullname: Hinkle
– volume: 294
  start-page: 1704
  year: 2001
  ident: 2020071612423829400_R11
  article-title: Identification of ubiquitin ligases required for skeletal muscle atrophy.
  publication-title: Science
  doi: 10.1126/science.1065874
  contributor:
    fullname: Bodine
– volume: 100
  start-page: 4420
  year: 2002
  ident: 2020071612423829400_R22
  article-title: Distal elements are critical for human CD34 expression in vivo.
  publication-title: Blood
  doi: 10.1182/blood-2002-03-0788
  contributor:
    fullname: Okuno
– volume: 286
  start-page: E642
  year: 2004
  ident: 2020071612423829400_R5
  article-title: Effect of sympathetic denervation on the rate of protein synthesis in rat skeletal muscle
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00371.2003
  contributor:
    fullname: Navegantes
– volume: 94
  start-page: 1058
  year: 2005
  ident: 2020071612423829400_R23
  article-title: Dexamethasone upregulates the expression of the nuclear cofactor p300 and its interaction with C/EBPβ in cultured myotubes.
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.20371
  contributor:
    fullname: Yang
– volume: 163
  start-page: 15
  year: 1999
  ident: 2020071612423829400_R27
  article-title: Pentoxifylline improves insulin action limiting skeletal muscle catabolism after infection.
  publication-title: J Endocrinol
  doi: 10.1677/joe.0.1630015
  contributor:
    fullname: Vary
– volume: 103
  start-page: 378
  year: 2007
  ident: 2020071612423829400_R36
  article-title: Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass.
  publication-title: J Appl Physiol
  doi: 10.1152/japplphysiol.00089.2007
  contributor:
    fullname: Frost
– volume: 281
  start-page: E449
  year: 2001
  ident: 2020071612423829400_R20
  article-title: Catecholamines inhibit Ca2+-dependent proteolysis in rat skeletal muscle through β2-adrenoceptors and cAMP
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.2001.281.3.E449
  contributor:
    fullname: Navegantes
– volume: 373
  start-page: 155
  year: 2003
  ident: 2020071612423829400_R37
  article-title: Characterization of the human, mouse and rat PGC1β (peroxisome-proliferator-activated receptor-γ co-activator 1β) gene in vitro and in vivo.
  publication-title: Biochem J
  doi: 10.1042/bj20030200
  contributor:
    fullname: Meirhaeghe
– volume: 26
  start-page: 95
  year: 1999
  ident: 2020071612423829400_R7
  article-title: Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscle from tumor-bearing rats.
  publication-title: Mol Biol Rep
  doi: 10.1023/A:1006955832323
  contributor:
    fullname: Combaret
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Snippet Although it is well known that catecholamines inhibit skeletal muscle protein degradation, the molecular underlying mechanism remains unclear. This study was...
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SubjectTerms 1-Methyl-3-isobutylxanthine - pharmacology
Adenosine monophosphate
Adrenergic beta-2 Receptor Agonists
Agonists
AKT protein
Animals
Atrophy
Biodegradation
Blotting, Western
Catecholamines
Cell Line
Clenbuterol
Clenbuterol - pharmacology
Cyclic AMP
Cyclic AMP - metabolism
Dexamethasone
Dexamethasone - pharmacology
Dietary restrictions
Forkhead Box Protein O3
Forkhead Transcription Factors - metabolism
FOXO3 protein
Gene expression
In Vitro Techniques
Inactivation
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
mRNA
Muscle Proteins - genetics
Muscle Proteins - metabolism
Muscle, Skeletal - cytology
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Myotubes
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Peroxisome proliferator-activated receptors
Phosphodiesterase inhibitors
Phosphodiesterase Inhibitors - pharmacology
Phosphorylation
Phosphorylation - drug effects
Proteasome Endopeptidase Complex - genetics
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Rats
Rats, Wistar
Receptors (physiology)
Receptors, Adrenergic, beta-2 - genetics
Receptors, Adrenergic, beta-2 - metabolism
Reverse Transcriptase Polymerase Chain Reaction
Skeletal muscle
SKP Cullin F-Box Protein Ligases - genetics
SKP Cullin F-Box Protein Ligases - metabolism
Trans-Activators - genetics
Trans-Activators - metabolism
Transcription Factors
Tripartite Motif Proteins
Ubiquitin - genetics
Ubiquitin - metabolism
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Title Mechanisms Involved in 3′,5′-Cyclic Adenosine Monophosphate-Mediated Inhibition of the Ubiquitin-Proteasome System in Skeletal Muscle
URI http://dx.doi.org/10.1210/en.2009-0428
https://www.ncbi.nlm.nih.gov/pubmed/19837877
https://www.proquest.com/docview/3130594270
https://search.proquest.com/docview/734153181
Volume 150
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